Instilling lignocaine(a local anaesthetic) through the endotracheal tube for prevention of cough during removal of endotracheal tube(extubation) and comparing its effectiveness to instilling normal saline

Not yet recruiting

• Conditions: Other cholelithiasis,

• Registration Number: CTRI/2023/03/050187
• Lead Sponsor: ESIC MEDICAL COLLEGE AND PGIMSR

Brief Summary

A typical clinical issue, coughing upon coming out of general anaesthesia can cause potentially harmful patient movements, hypertension, tachycardia or other arrhythmias, myocardial ischaemia, surgical haemorrhage, bronchospasm, and a rise in intracranial and intraocular pressure.

In individuals with coronary artery disease, cerebrovascular disease, or intracranial hypertension, coughing during extubation may have harmful implications.

Lidocaine is a local anaesthetic which has long been used to obtund intubation response. According to studies, stimulation of the larynx, trachea, and carina all result in haemodynamic abnormalities that lidocaine prevents. The larynx is the one that causes the greatest reaction among them.Endotracheal instillation of Lidocaine in the cuff in order to inflate the cuff prevents coughing and thereby prevents an increase in blood pressure and heart rate throughout the surgery. But repeated instillation may be required as it may get absorbed through the cuff. Endotracheal instillation of Lidocaine has been shown to obtund intubation response. Similar instillation through the endotracheal tube to obtund the response to extubation is sparsely studied.

The aim of the study is to investigate whether endotracheal instillation of lignocaine attenuates cough and airway circulatory reflex during extubation after elective laparoscopic surgeries requiring general anaesthesia.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-02-27
• Study Start: 2023-06-03

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

• 1.Patient willing to give informed consent (Annexure-1) 2.American Society of Anesthesiologists (ASA) physical status I or II.
• (Annexure 2) 3.Elective laparoscopic surgical procedures of a duration of 1-1.5hours under general anaesthesia with requirement for endotracheal intubation.

Exclusion Criteria

• 1.Patient with risk factors for difficult airway (mouth opening of <2cm, Mallampatti class 4, limited neck extension, history of previous difficult intubation) 2.Patients with known pulmonary and cardiovascular diseases.
• 3.Patients having sore throat or active Upper Respiratory Infection (URI), history of laryngeal or tracheal pathology/surgery, history of asthma or Chronic Obstructive Pulmonary Disease(COPD).
• 4.Known allergy to local anaesthetic.
• 5.Patients on beta-blocker therapy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
NUMBER AND GRADE OF COUGH	At base line (during extubation)

Secondary Outcome Measures

Name	Time	Method
HEART RATE AND BLOOD PRESSURE	EVERY MINUTE UPTO 10 MINS AFTER EXTUBATION

Trial Locations

Locations (1)

ESIC MEDICAL COLLEGE AND PGIMSR; 🇮🇳 Bangalore, KARNATAKA, India

ESIC MEDICAL COLLEGE AND PGIMSR

🇮🇳Bangalore, KARNATAKA, India

HARI PRABHAKAR K

Principal investigator

88388632729

hariprabhakar.kumar@gmail.com