Effects of Different Deflation Methods on Coughing Response and Hemodynamics During Extubation

Not Applicable

Recruiting

• Conditions: Deflating Method

• Registration Number: NCT05647395
• Lead Sponsor: Zhuan Zhang

Brief Summary

Patients with endotracheal intubation and general anesthesia often have severe choking and hemodynamic fluctuations during the extubation period, which increases the risk of cerebrovascular accident, arrhythmia, incision bleeding and so on . This study aimed to observe the effects of different methods of deflating of endotracheal tube cuffs on cough response and hemodynamics during periextubation in patients undergoing general anesthesia surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-01
• Study First Submitted: 2022-11-21
• Status Verified: 2022-12
• Study First Submitted QC: 2022-12-09
• Last Update Submitted: 2022-12-09
• Study First Posted: 2022-12-12
• Last Update Posted: 2022-12-12
• Primary Completion: 2023-07-30
• Study Completion: 2024-07-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

1. Elective endotracheal intubation under general anesthesia.
2. Operation time < 3 h.
3. ASA grade I or II.
4. Age 18~65 years old.

Exclusion Criteria

1. Throat and neck surgery.
2. Those assessed to have a high risk of reflux aspiration.
3. Difficulty intubation.
4. History of snoring before surgery.
5. Recent respiratory illness such as chronic cough.
6. Previous airway hyperresponsiveness, such as asthma.
7. recent use of cough suppressants.
8. Patients with severe heart, liver and kidney diseases.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Grading of cough reaction	During extubation procedure	Grading of cough reactions
Change in Blood pressure	Preoperatively, immediately before extubation, immediately after extubation, 1 minute after extubation, 3 minutes after extubation, 10 minutes after extubation	Hemodynamics
Change in Heart rate	Preoperatively, immediately before extubation, immediately after extubation, 1 minute after extubation, 3 minutes after extubation, 10 minutes after extubation	Hemodynamics

Secondary Outcome Measures

Name	Time	Method
Adverse reactions	Within 24 hours after removal of the endotracheal tube	Hypoventilation, pharyngeal discomfort, hoarseness

Trial Locations

Locations (1)

the Affiliated Hospital of Yangzhou University, Yangzhou University; 🇨🇳 Yangzhou, Jiangsu, China