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Clinical Trials/ISRCTN25258560
ISRCTN25258560
Completed
Not Applicable

Multicentre trial of continuous Positive Airway Pressure for chronic therapy of heart failure

niversity Health Network (Toronto) (Canada)0 sites408 target enrollmentJune 17, 2005
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ConditionsCongestive heart failureCirculatory SystemHeart failure

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Congestive heart failure
Sponsor
niversity Health Network (Toronto) (Canada)
Enrollment
408
Status
Completed
Last Updated
11 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
June 17, 2005
End Date
TBD
Last Updated
11 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
niversity Health Network (Toronto) (Canada)

Eligibility Criteria

Inclusion Criteria

  • •1\. Male and females between the age of 18 and 79 with history of at least one clinical episode of CHF due to ischaemic heart failure
  • •2\. Left ventricular (LV) systolic dysfunction as evidenced by a left ventricular ejection fraction (LVEF) at rest determined by equilibrium radionuclide angiography of less than 40% while on optimal drug therapy at the time of recruitment
  • •3\. New York Heart Association (NYHA) functional class two to four
  • •4\. Stable condition and stable optimal cardiac medications for at least one month prior to entry
  • •5\. Presence of central sleep apnoea defined as more than or equal to 15 apnoeas and hypopneas per hour of sleep of which more than 50% must be central in nature
  • •6\. Written informed consent

Exclusion Criteria

  • •1\. History of unstable angina, cardiac surgery and/or documented myocardial infarction less than three months prior to entry into the study
  • •2\. Acceptance for cardiac transplantation
  • •3\. Sleep apnea which is predominantly (i.e. more than or equal to 50%) obstructive in nature
  • •4\. Concurrent disease that would markedly limit life expectancy (e.g. lung cancer)
  • •5\. Pregnancy

Outcomes

Primary Outcomes

Not specified

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