ISRCTN25258560CompletedNot Applicable
Multicentre trial of continuous Positive Airway Pressure for chronic therapy of heart failure
niversity Health Network (Toronto) (Canada)0 sites408 target enrollmentStarted: June 17, 2005Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 408
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •1. Male and females between the age of 18 and 79 with history of at least one clinical episode of CHF due to ischaemic heart failure
- •2. Left ventricular (LV) systolic dysfunction as evidenced by a left ventricular ejection fraction (LVEF) at rest determined by equilibrium radionuclide angiography of less than 40% while on optimal drug therapy at the time of recruitment
- •3. New York Heart Association (NYHA) functional class two to four
- •4. Stable condition and stable optimal cardiac medications for at least one month prior to entry
- •5. Presence of central sleep apnoea defined as more than or equal to 15 apnoeas and hypopneas per hour of sleep of which more than 50% must be central in nature
- •6. Written informed consent
Exclusion Criteria
- •1. History of unstable angina, cardiac surgery and/or documented myocardial infarction less than three months prior to entry into the study
- •2. Acceptance for cardiac transplantation
- •3. Sleep apnea which is predominantly (i.e. more than or equal to 50%) obstructive in nature
- •4. Concurrent disease that would markedly limit life expectancy (e.g. lung cancer)
- •5. Pregnancy
Investigators
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