Muscle Activation in Knee Osteoarthritis
- Conditions
- Knee Osteoarthritis
- Interventions
- Device: Electromyography (EMG) measurement
- Registration Number
- NCT05870033
- Lead Sponsor
- University of Pecs
- Brief Summary
Muscle activity, as a possible fundamental cause of functional limitation, has been extensively investigated in knee osteoarthritis (KOA). Many trials investigated muscle activity during dynamic movements and functional tasks in KOA. In addition, gender-related differences has been also investigated during functional movements in KOA. However, no trial investigated gender-related differences in muscle activation during static movement in KOA.
- Detailed Description
Muscle activity, as a possible fundamental cause of functional limitation, has been extensively investigated in knee osteoarthritis (KOA). Interestingly, studies concentrated mainly on investigation of muscle activity during dynamic movements and different functional tests. Moznuzzaman et al displayed greater muscle activation during sitting to standing test (STS) and standing to sitting test in KOA patients compared to healthy participants. Interestingly, some studies investigated muscle activation standing up from a knee-height seat during STS and illustrated a greater muscle activation amongst KOA patients compared to healthy controls. Moreover, Amer et al found greater muscle activation while performing STS from a lower height seat compared to a knee-height seat amongst women and men patients with uni/bilateral KOA. These findings might be of interest due to compensatory mechanisms observed by female patients during STS transition increases loading on the joint surfaces and consequently leading to progression of KOA. Furthermore, different studies also presented gender-differences of muscle activation during different weight-bearing tasks (gait, STS, stair ascend/descend, and squat) amongst patients with KOA and healthy control. Interestingly, both studies showed women with KOA representing higher muscle activation compared to men. Therefore, an analytical comparative study might be useful for identification of gender-differences in muscle activation amongst patients with KOA.
Investigation of static muscle activity during functional movements is very rare in KOA. Zhang et al investigated muscle activation after single whole body vibration trial in standing position at 0°, 30° and 60° static knee flexion angles amongst women with KOA. Authors found that muscle activation in 60° was greater compared to 30°, and it was also greater in 30° compared to 0°. Based on our literature search, no further study examined muscle activity in static knee flexion in KOA. However, investigating static knee flexion might be useful as it could be related to different knee moments in KOA.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 70
- radiologically diagnosed KOA based on the Kellgren-Lawrence grading system 1-3,
- age above 60 years
- at least 60° active knee flexion
- sufficient mental status
- acute inflammation of the knee
- intraarticular injections within the last 3 months
- total knee replacement in the opposite side
- class II obesity (body mass index, BMI>35kg/m2)
- severe degenerative lumbar spine disease (e.g., spondylolisthesis)
- systemic inflammatory arthritic or neurological condition
- conservative intervention attendance within 6 months
- contraindication to conservative therapy and manual therapy
- unstable heart condition
- complex regional pain syndrome
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Men group Electromyography (EMG) measurement Muscle activity amongst men with KOA Women group Electromyography (EMG) measurement Muscle activity amongst women with KOA
- Primary Outcome Measures
Name Time Method Patients' baseline pain within 1 day Measurement of patients' pain based on Numeric Pain Rating Scale
Muscle activation during stepping up a stair within 1 day EMG measurement of muscle activation during stepping up on a stair
Muscle activation during stepping down a stair within 1 day EMG measurement of muscle activation during stepping down from a stair
Patients' baseline state within 1 day Measurement of patients' pain, stiffness and functional state based on WOMAC
Muscle strength of hamstring muscles within 1 day Measurement of muscle strength of m. semitendinosus, semimembranosus and biceps femoris in 0, 35 and 60 degree
Patients' baseline knee flexion within 1 day Measurement of patients' active knee flexion in supine
Muscle activation in 30 degree static knee flexion within 1 day EMG measurement of muscle activation during 2-leg 30 degree static knee flexion
Muscle activation during stepping down side-ways a stair with affected leg within 1 day EMG measurement of muscle activation during stepping down side-ways a stair with affected leg
Muscle activation in one-leg standing position within 1 day EMG measurement of muscle activation in one-leg standing position
Patients' baseline knee flexion in standing position within 1 day Measurement of patients' active knee flexion during weight-bearing
Muscle strength of m. quadriceps femoris within 1 day Measurement of muscle strength of m. quadriceps femoris in 0, 35 and 60 degree
Muscle activation during stepping down side-ways a stair with opposite leg within 1 day EMG measurement of muscle activation during stepping down side-ways a stair with opposite leg
Muscle activation in 60 degree static knee flexion within 1 day EMG measurement of muscle activation during 2-leg 60 degree static knee flexion
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Pécs
🇭🇺Pécs, Baranya, Hungary