Characterization of Neuromuscular Function and Fatigue After Breast Cancer Treated With Adjuvant Chemotherapy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Breast Cancer
- Sponsor
- Institut de cancérologie Strasbourg Europe
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Maximal isometric muscle strength for knee extensors
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This is a transversal monocentric study comparing two groups of women (group 1, patient group : patients who have been treated for a breast cancer with taxane-based chemotherapy ; group 2, control group : healthy volunteers). The aim of this study is to evaluate if a difference exists regarding the maximal isometric muscle strength between group 1 and 2.
Detailed Description
All subjects will be evaluated a single time during two hours. For patients from group 1 the evaluation should take place within the two weeks that follow the end of adjuvant treatment. There is no specificity regarding evaluation of volunteers from group 2, their evaluation can take place at any time.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Group 1 - Patients :
- •\< 18 years old or patients ≥ 18 years old under guardianship, or supervision
- •Psychiatric, musculoskeletal or neurologic disorders
- •Patients presenting one of the following contraindications to transcranial magnetic stimulation :
- •Presence of a implanted metallic foreign-body (cochlear implant, drug pump system, pacemaker, etc.)
- •History of epilepsy
- •Brain injury (vascular, traumatic, tumour-induced, infectious or metabolic)
- •Women that are pregnant
- •Serious or recent heart disease
- •Group 2 -Control group :
Outcomes
Primary Outcomes
Maximal isometric muscle strength for knee extensors
Time Frame: At Inclusion
Measured with force sensors. Significant differences between the two groups will be assessed
Secondary Outcomes
- Number of Participants with neuromuscular fatigue(At Inclusion)
- Number of Participants with muscle architecture.(At Inclusion)
- Number of Participants with body composition.(At Inclusion)
- Number of Participants with subjective fatigue.(At Inclusion)