Adipose Tissue Function and Response to Exercise Training in Women With and Without Polycystic Ovary Syndrome
- Conditions
- Polycystic Ovary Syndrome
- Interventions
- Behavioral: 4x4 minutes high intensity interval trainingBehavioral: 10x1 minute high intensity interval training
- Registration Number
- NCT02943291
- Lead Sponsor
- Norwegian University of Science and Technology
- Brief Summary
The primary aim of this trial is to investigate adipose tissue function in women with and without polycystic ovary syndrome (PCOS). PCOS is a common endocrine disorder in young women. The pathogenesis behind PCOS is complex and only partly understood, and deeper mechanistic insight is needed. Insulin resistance is a central feature of PCOS, and recent studies have suggested that this is linked to aberrant adipose tissue function. Exercise training has been found to improve the symptoms in PCOS, but we need more knowledge about why. While processes involved in skeletal muscle oxidative remodeling are well described, it is to a large extent unknown whether the oxidative capacity of human adipose tissue is modified by endurance training. The women included in this study will be matched (for body mass index, body weight, and age) to participants in another study. This will enable the investigators to do a comparison between cases (women with PCOS) and controls (women without PCOS) at baseline, and to assess the responses to exercise training in adipose tissue.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 15
- eumenorrheic
- matching PCOC group in IMPROV-IT study (NCT02419482)
- Living nearby St Olavs Hospital, Trondheim, Norway
- Signs of hyperandrogenism
- Regular high intensity endurance (two or more times per week of vigorous exercise).
- Concurrent treatments (insulin sensitizers or drugs known to affect gonadotropin or ovulation, with a wash out period of 1 months prior to inclusion).
- On-going pregnancy
- Hormonal contraception
- Breastfeeding within 24 weeks
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 4x4 minutes interval training 4x4 minutes high intensity interval training 4x4 minutes high intensity interval training with 4 minute intervals 10x1 minute interval training 10x1 minute high intensity interval training 10x1 minute high intensity interval training with 1 minute intervals
- Primary Outcome Measures
Name Time Method mitochondrial oxidative phosphorylation capacity 16 weeks assessed with high resolution respirometry
production of reactive oxygen species 16 weeks assessed with high resolution respirometry
- Secondary Outcome Measures
Name Time Method blood glucose 16 weeks Adipokine secretion 16 weeks lipid droplet size in adipocytes 16 weeks Whole-body peak oxygen uptake 16 weeks Adipokine gene expression 16 weeks blood pressure 16 weeks Intima media thickness 16 weeks measured by ultrasound
HDL cholesterol in blood 16 weeks Body composition 16 weeks assessed by impedance scale (InBody)
Glycosylated Hemoglobin (HbA1c) in blood 16 weeks Whole-body fat oxydation rate 16 weeks Insulin sensitivity 16 weeks 2h oral glucose tolerance test (OGGT)
Total protein abundance in adipose tissue 16 weeks quantified using standard Western Blot method
"blood markers of cardiometabolic health" 16 weeks blood insulin 16 weeks endothelial function 16 weeks measured by flow-mediated dilatation of the brachial artery
Total cholesterol in blood 16 weeks LDL cholesterol in blood 16 weeks
Trial Locations
- Locations (2)
Centre of Exercise and Nutrition, Mary MacKillop Institute for Health Research, AUC
🇦🇺Melbourne, Australia
Department of circulation and medical imaging , NTNU
🇳🇴Trondheim, Norway