Adipose Tissue Function and Response to Exercise Training in Women With and Without Polycystic Ovary Syndrome
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Polycystic Ovary Syndrome
- Sponsor
- Norwegian University of Science and Technology
- Enrollment
- 15
- Locations
- 2
- Primary Endpoint
- mitochondrial oxidative phosphorylation capacity
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The primary aim of this trial is to investigate adipose tissue function in women with and without polycystic ovary syndrome (PCOS). PCOS is a common endocrine disorder in young women. The pathogenesis behind PCOS is complex and only partly understood, and deeper mechanistic insight is needed. Insulin resistance is a central feature of PCOS, and recent studies have suggested that this is linked to aberrant adipose tissue function. Exercise training has been found to improve the symptoms in PCOS, but we need more knowledge about why. While processes involved in skeletal muscle oxidative remodeling are well described, it is to a large extent unknown whether the oxidative capacity of human adipose tissue is modified by endurance training. The women included in this study will be matched (for body mass index, body weight, and age) to participants in another study. This will enable the investigators to do a comparison between cases (women with PCOS) and controls (women without PCOS) at baseline, and to assess the responses to exercise training in adipose tissue.
Investigators
Eligibility Criteria
Inclusion Criteria
- •eumenorrheic
- •matching PCOC group in IMPROV-IT study (NCT02419482)
- •Living nearby St Olavs Hospital, Trondheim, Norway
Exclusion Criteria
- •Signs of hyperandrogenism
- •Regular high intensity endurance (two or more times per week of vigorous exercise).
- •Concurrent treatments (insulin sensitizers or drugs known to affect gonadotropin or ovulation, with a wash out period of 1 months prior to inclusion).
- •On-going pregnancy
- •Hormonal contraception
- •Breastfeeding within 24 weeks
Outcomes
Primary Outcomes
mitochondrial oxidative phosphorylation capacity
Time Frame: 16 weeks
assessed with high resolution respirometry
production of reactive oxygen species
Time Frame: 16 weeks
assessed with high resolution respirometry
Secondary Outcomes
- blood glucose(16 weeks)
- Adipokine secretion(16 weeks)
- lipid droplet size in adipocytes(16 weeks)
- Whole-body peak oxygen uptake(16 weeks)
- Adipokine gene expression(16 weeks)
- blood pressure(16 weeks)
- Intima media thickness(16 weeks)
- HDL cholesterol in blood(16 weeks)
- Body composition(16 weeks)
- Glycosylated Hemoglobin (HbA1c) in blood(16 weeks)
- Whole-body fat oxydation rate(16 weeks)
- Insulin sensitivity(16 weeks)
- Total protein abundance in adipose tissue(16 weeks)
- "blood markers of cardiometabolic health"(16 weeks)
- blood insulin(16 weeks)
- endothelial function(16 weeks)
- Total cholesterol in blood(16 weeks)
- LDL cholesterol in blood(16 weeks)