Validation of 3.0 Tesla 1H-MR Spectroscopy for assessment of liver steatosis in patients with non-alcoholic fatty liver disease and chronically infected hepatitis C

• Conditions: fatty liver; hepatitis C; jaundice; liversteatosis; 10019654

• Registration Number: NL-OMON31271
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Patients over 18 years of age
Patients with signs of non-alcoholic fatty liver disease and who require liver biopsy for steatosis assessment
Patients chronically infected with hepatitis C and who require liver biopsy

Exclusion Criteria

Patients under 18 years of age
Patients who are pregnant
Hepatitis C patients with HOMA-IR score < 2
Hepatitis C patients with alcohol consumption of > 40 grams per week
Patients who are claustrophobic
Patients who have magnetic or radiofrequency sensitive implants
Patients with extreme obesity (maximum weight limit MRI scanner 140kg)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Validation and quantification of hepatic steatosis with 3.0 Tesla 1H-MRS in<br /><br>patients with non-alcoholic fatty liver disease or chronically infected<br /><br>hepatitis C and correlation with histological analysis of the liver biopsy and<br /><br>clinical parameters</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>nvt</p><br>