How effective is tranexamic acid in controlling post-surgical drainage after neck dissection surgery in patients with the oral cancers
- Conditions
- eck Drain output after Tumor Resection and Neck Dissection Surgery for Oral Cance3.Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
- Registration Number
- IRCT20231019059765N1
- Lead Sponsor
- CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 44
Patients 18 years of age or older
Patients who will undergo supraomohyoid neck dissection due to oral, head and neck cancers.
Patients who consent to be part of this study, who are willing and able to comply with the protocols of the study.
Patients who have a history of hypersensitivity or any adverse reaction to tranexamic acid or any of its components.
Patients having thromboembolic events in the past or any related disorder like pulmonary embolism or DVT.
Patients who have bleeding disorders.
Patients having contraindications to TXA, such as renal failure/disease or active thromboembolic disease.
Patients who are on anticoagulant or antiplatelet therapy that can not be stopped for this surgery.
Patients who do not wish to provide informed consent and are unwilling to be part of the study.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Post-operative drainage for the first 24 hrs., first 5 days and the day of removal of drain are the primary outcomes. Timepoint: First 24 hours following surgery, first 5 days, and day of removal of drain. Method of measurement: Measurements in milliliters on vacuum suction drain bottle.
- Secondary Outcome Measures
Name Time Method Whereas the secondary outcomes are surgical site infection (grade of infection), hematoma formation, flap necrosis for neck dissection complications. Timepoint: Day 1 to day 5 till drain removal. Method of measurement: Clinical Examination and visual analogue scale.