Influence of one-lung-ventilation on the integrity of cerebrovascular autoregulatio
Recruiting
- Conditions
- cerebral autoregulation
- Registration Number
- DRKS00019204
- Lead Sponsor
- Klinik für Anästhesiologie, Universitätsmedizin Mainz
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 101
Inclusion Criteria
Patients meeting the following criteria are included in the study:
- Age = 18 years
- Ability to consent
- RAMIE (robotic assisted minimally invasive esophagectomy, DaVinci)
Exclusion Criteria
Patients who fulfill only one of the following criteria are not included in the study:
- Pregnancy and breastfeeding
- missing temporal ultrasound window
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome is if and to what extent an impairment of the cerebral autoregulation occurs during one lung ventilation as part of the robotic assisted minimal invasive esophagectomy (RAMIE, DaVinci®). The data will be gathered during the surgery.
- Secondary Outcome Measures
Name Time Method Secondary outcomes are: <br>1) Comparability of the calculation of cerebrovascular autoregulation capacity using NIRS and the gold standard TCD<br>2) Characteristic of the time course in the integrity of the cerebrovascular autoregulation<br>3) Functional observation of the relationship between the cerebrovascular autoregulatory capacity and the end-expiratory and arterial CO2 partial pressure respectively<br>4) Measurement of changes in cerebral oxygen saturation during one lung ventilation<br>5) Identification of critical surgical moments, which cause a disruption of autoregulatory capacity or cerebral oxygen saturation / homeostasis and should be subject to special anesthesiological observation in the future<br>6) Changes in cerebral blood flow velocity