Effect of Mango on Gut Microbiota and Metabolic Health
Not Applicable
- Conditions
- Gut MicrobiotaMetabolic Syndrome
- Interventions
- Dietary Supplement: Mango consumption
- Registration Number
- NCT03825276
- Lead Sponsor
- Laval University
- Brief Summary
Mango is rich in bioactive compounds such as dietary polyphenols and carotenoids, which may explain its beneficial effect on health. Polyphenols accumulate in the gut where they can positively modulate the microbiota. As gut microbiota may have a strong influence on cardiometabolic health, we hypothesize that mango consumption improves metabolic profile in overweight or obese individuals through beneficial changes in gut microbiota. The study of metagenomics, transcriptomics and metabolomics will be used to validate this hypothesis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 35
Inclusion Criteria
- Healthy men and premenopausal women
- At least one of the following : BMI between 25 and 40 kg/m2 or Waist circumference ≥ 80 cm for women and ≥ 94 cm for men
- At least one of the following : TG ≥ 1.35 mmol/L or fasting insulinemia ≥ 42 pmol/L
- Caucasian origin
Exclusion Criteria
- Nicotine use
- Metabolic disorders or use of medication that may affect parameters measured in the study
- Use of dietary supplements or natural health product that may affect parameters measured in the study
- Use of antibiotics in the last 3 months
- Surgery in the last 3 months or planned during the study timeline
- Alcohol consumption >2 drinks/day
- Weight change >5% in the last 3 months
- Mango aversion, allergy or intolerance
- Dietary restrictions (vegetarian, gluten avoidance...)
- Berries consumption >1 serving/day
- Pregnancy, breastfeeding or pregnancy planned within 3-6 months
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Mango consumption Mango consumption -
- Primary Outcome Measures
Name Time Method Changes in plasma triglycerides concentration of overweight/obese men and women taking frozen mangos daily 8 weeks Changes in plasma insulin concentration of overweight/obese men and women taking frozen mangos daily 8 weeks Changes in plasma total cholesterol concentration of overweight/obese men and women taking frozen mangos daily 8 weeks Changes in plasma glucose concentration of overweight/obese men and women taking frozen mangos daily 8 weeks Changes in plasma HDL cholesterol concentration of overweight/obese men and women taking frozen mangos daily 8 weeks Changes in plasma LDL cholesterol concentration of overweight/obese men and women taking frozen mangos daily 8 weeks
- Secondary Outcome Measures
Name Time Method Changes in insulin sensitivity of overweight/obese men and women taking frozen mangos daily 8 weeks Changes in glycated hemoglobin (HbA1c) in overweight/obese men and women taking frozen mangos daily 8 weeks Changes in diastolic blood pressure of overweight/obese men and women taking frozen mangos daily 8 weeks Changes in plasma lipopolysaccharide (LPS) concentration of overweight/obese men and women taking frozen mangos daily 8 weeks Changes in waist circumference of overweight/obese men and women taking frozen mangos daily 8 weeks Height of overweight/obese men and women taking frozen mangos daily Baseline Changes in body mass index (BMI) of overweight/obese men and women taking frozen mangos daily 8 weeks Weight and height will be combined to report BMI
Changes in systolic blood pressure of overweight/obese men and women taking frozen mangos daily 8 weeks Changes in insulin secretion of overweight/obese men and women taking frozen mangos daily 8 weeks Changes in plasma interleukin-6 (IL-6) concentration of overweight/obese men and women taking frozen mangos daily 8 weeks Changes in waist to hip circumference ratio of overweight/obese men and women taking frozen mangos daily 8 weeks Waist and hip circumference will be combined to report waist to hip ratio
Changes in weight of overweight/obese men and women taking frozen mangos daily 8 weeks Changes in hip circumference of overweight/obese men and women taking frozen mangos daily 8 weeks Changes in plasma high-sensitivity C-reactive protein (hs-CRP) concentration of overweight/obese men and women taking frozen mangos daily 8 weeks Changes in gene expression in peripheral blood mononuclear cells (PBMC) of overweight/obese men and women taking frozen mangos daily 8 weeks Gene-level expression from \>20,000 annotated genes will be examined
Changes in plasma metabolites concentration in overweight/obese men and women taking frozen mangos daily 8 weeks Metabolites include acylcarnitines, glycerophospholipids, sphingolipids, sugars, amino acids, biogenic amines
Changes in gut microbiota composition in overweight/obese men and women taking frozen mangos daily 8 weeks Stool samples will be collected and whole metagenome shotgun sequencing analysis will be conducted
Changes in plasma tumor necrosis factor (TNF-alpha) concentration of overweight/obese men and women taking frozen mangos daily 8 weeks Changes in plasma LPS binding protein (LBP) concentration of overweight/obese men and women taking frozen mangos daily 8 weeks
Trial Locations
- Locations (1)
Laval University
🇨🇦Québec, Canada