Immune and Cognitive Benefits of Mango Intake in Young Adults

Not Applicable

Not yet recruiting

• Conditions: Cognition; Immunity
• Interventions: Dietary Supplement: Mango group

• Registration Number: NCT06229262
• Lead Sponsor: Loma Linda University

Brief Summary

The main objectives of our proposed study are to determine the effects of mango consumption on immune and cognitive functions in free-living college going young adults aged 18-30 years

Detailed Description

The main objectives of our proposed study are to determine the effects of mango consumption on immune and cognitive functions in free-living college going young adults aged 18-30. To accomplish these objectives, a randomized controlled, parallel design study is proposed with two groups consuming their habitual diet, but with one (Mango group) receiving 1.5 servings of mango/day and the other (Control group) abstaining from eating any mango for the duration of the study.

Study Timeline

• Study First Submitted: 2024-01-19
• Study First Submitted QC: 2024-01-19
• Study First Posted: 2024-01-29
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-19
• Last Update Posted: 2025-05-21
• Study Start: 2025-10
• Primary Completion: 2026-10
• Study Completion: 2026-10

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

• Male and female college students aged 18-30 years

Exclusion Criteria

• known intolerance or allergy to mangos
• regular intake of mangos and/or fruits of a similar nutritional content such as peach, nectarine, papaya, apricot and cantaloupe
• using cognition and/or immune-boosting supplements or vitamins
• recent exposure to antibiotics and corticoids
• uncontrolled chronic diseases and mental illnesses, clinical depression, and immunocompromised state

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Mango Group	Mango group	Participants in the Mango group will consume 1.5 cups of mangos for 12 weeks

Primary Outcome Measures

Name	Time	Method
Changes in lymphocyte populations	baseline to 12 weeks	Immunophenotyping will be performed by flow cytometry to measure the number of T helper, T cytotoxic, Naive and memory cells and B cells
Changes in Lymphocyte activity	baseline to 12 weeks	The production of lymphocytes will be measured in the supernatant using enzyme linked immunosorbent assay (ELISA)
Changes in cytokine production	baseline to 12 weeks	The cytokines produced due to lymphocyte activity will be measured in the supernatant using enzyme linked immunosorbent assay (ELISA)
Changes in serum inflammatory cytokine concentration	baseline to 12 weeks	changes in the concentrations of the inflammatory cytokines will be performed on serum using enzyme linked immunoassay (ELISA) will include hs-CRP, interleukin (IL)-1B, IL-6, TNF a, IL-10, IL-2, IFN-γ, E-selectin,
changes from baseline in global cognitive composite score	baseline to 12 weeks	The composite score will be calculated using the scores from the tests listed below. Scores will be calculated with the standardized scores of each test as the score of each participant minus the group mean and divide by its standard deviation. The composite score is the mean of the standardized scores. the 5 tests are: Rey Auditory Verbal Learning Test (RAVLT), Brief Visuospatial Memory Test, Digit Span, FAS Word Fluency, Symbol Digit Modalities Test
Change in serum brain-derived neurotrophic factor (pg/mL)	baseline to 12 weeks	changes in serum brain-derived neurotrophic factor (pg/mL) assessed by ELISA

Trial Locations

Locations (1)

Loma Linda University School of Public Health; 🇺🇸 Loma Linda, California, United States