Effects of Mango Intake on Skin Health and Gut Microbiome Changes in Postmenopausal Women

Not Applicable

• Conditions: Photoaging
• Interventions: Other: Food

• Registration Number: NCT04869852
• Lead Sponsor: Integrative Skin Science and Research

Brief Summary

Mangos are a rich source of nutrients such as carotenoids, vitamin C and fiber, as well as polyphenols and phenolic acids such as mangiferin, ellagic acid, and gallotannins. Mango extract has been reported to protect against photo-aging of the skin in an animal model exposed to UVB radiation, reducing the length of wrinkles and increasing collagen bundles. Beta-carotene and other carotenoids are known to provide skin protection from sunlight, but other compounds in mangos, may also be important in reducing oxidative damage in aging skin.

We have recently completed a pilot study showing a clear trend in skin wrinkle reduction when postmenopausal women consumed 85g of Ataulfo mangos, four times per week for 16 weeks. To confirm and extend these results, a larger study is proposed.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-04-29
• Study First Submitted QC: 2021-04-29
• Status Verified: 2021-05
• Study First Posted: 2021-05-03
• Last Update Submitted: 2021-05-18
• Last Update Posted: 2021-05-20
• Study Start: 2021-05-30
• Primary Completion: 2022-06-30
• Study Completion: 2023-06-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 70

Inclusion Criteria

• 50 - 70 years old
• Postmenopausal
• Fitzpatrick skin type I, II, or III
• BMI 18.5 - 35
• Must be willing to comply with all protocol requirements
• Must be willing to have flash photo facial images taken with the imaging systems

Exclusion Criteria

• Smokers
• Allergy to mangos
• Vegans/vegetarians
• Adults unable to consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Mango	Food	85g mango, 4x/week

Primary Outcome Measures

Name	Time	Method
Wrinkles	week 20	Wrinkle score measured by Facial Image Analysis System

Secondary Outcome Measures

Name	Time	Method
Facial Hydration	week 20	Moisture measured by MoistureMeterSC
Facial Redness	week 20	Redness measured by Facial Image Analysis System
Gut microbiome	week 20	Analyze for the relative abundance of short chain fatty acid producing bacteria
Facial Elasticity	week 20	measured by Cutometer