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临床试验/NCT07191769
NCT07191769
尚未招募
不适用

The Effect of the Selected Anaesthesia Method on Morbidity and Mortality in Frail Patients Scheduled for Transurethral Surgery

Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey0 个研究点目标入组 180 人开始时间: 2025年10月1日最近更新:

概览

阶段
不适用
状态
尚未招募
发起方
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
入组人数
180
主要终点
Postoperative morbidity

概览

简要总结

The aim of this study is to comparatively evaluate the effects of different anaesthesia methods (spinal anaesthesia and general anaesthesia) administered to frail elderly patients scheduled for transurethral surgery (e.g. TUR-Prostate or TUR-Bladder) on postoperative morbidity and mortality rates.

详细描述

When planning transurethral surgery in frail patients, optimising the anaesthesia method is critical in minimising perioperative risks. In a 2021 study by Darwish et al. (1), 28,486 TUR-P cases were grouped according to the selected anaesthesia method. The 30-day mortality rate was 0.4% in the neuroaxial anaesthesia (spinal/epidural) group and 0.7% in the general anaesthesia group; the neuroaxial anaesthesia group showed significantly better outcomes in terms of secondary morbidity rates such as mortality and sepsis. However, there are studies in the literature supporting general anaesthesia. A study by Ayoub et al. (4) emphasised that in frail patients, similar morbidity rates can be achieved with general anaesthesia or spinal anaesthesia; spinal anaesthesia may increase the risk of hypotension and bradycardia. Based on these studies, the selection of the appropriate anaesthesia method for transurethral procedures is of critical importance in terms of patient morbidity and mortality rates. This study aims to contribute to clinical guidelines by clarifying which type of anaesthesia is safer in this specific demographic and clinical group. Within the scope of the research, parameters such as complications associated with the anaesthesia method, length of hospital stay, readmission rate, and 30-day mortality are analysed with the aim of determining the most appropriate and safest anaesthesia method for the vulnerable patient group.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
65 Years 至 —(Older Adult)
性别
All
接受健康志愿者

入选标准

  • Elderly patients aged 65 and over
  • ASA (American Society of Anaesthesiologists) physical condition classification I-III patients
  • meeting the criteria for frailty

排除标准

  • Non-elective emergency surgeries
  • Patients under 65 years of age
  • Patients classified as ASA Class IV
  • Patients unable to provide informed consent due to cognitive impairment
  • Patients who have previously undergone major neurological or cardiac surgery

结局指标

主要结局

Postoperative morbidity

时间窗: 30-day postoperative morbidity

Morbidity rates up to the 30th day postoperatively will be recorded. Patients will be contacted by phone and the data will be recorded.

Postoperative mortality

时间窗: 30-day postoperative mortality

Mortality rates up to the 30th day postoperatively will be recorded. Patients will be contacted by phone and the data will be recorded.

次要结局

  • Duration of surgery(Until the end of the surgery)
  • Length of hospital stay(first week after surgery)
  • intraoperative complications,(perioperative period)

研究者

发起方
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
申办方类型
Other
责任方
Sponsor

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