Effect of increased uric acid levels on fall in blood pressure following spinal anesthesia
Not Applicable
Completed
- Conditions
- Health Condition 1: null- singleton pregnancy with pre-eclampsia, requiring cesarean delivery under subarachnoid block
- Registration Number
- CTRI/2017/02/007927
- Lead Sponsor
- PGIMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
This study will be conducted in a total of 80 pre-eclamptic parturients, with singleton pregnancy, taken up for non elective cesarean delivery under spinal anaesthesia
Exclusion Criteria
-Any contraindication to spinal anaesthesia
-Gestation below 32 weeks
-Local or generalized sepsis
-Twin pregnancy
-Presence of hyperuricemia before pregnancy
-Pre existing heart disease, liver or renal disorders
-Pre existing or gestational diabetes mellitus and chronic hypertension
-Pre-eclampsia parturients who are on therapeutic doses of magnesium sulphate for severe features
-Patient refusal
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.The incidence of post-spinal hypotension (fall of more than 20% of MAP from baseline values) in pre-eclamptic parturients with raised serum uric acid levels.Timepoint: non-invasive blood pressure (NIBP) will be taken at 1-min interval till the birth of the baby and then every 5 minutes
- Secondary Outcome Measures
Name Time Method 1.Total amount of vasopressor administered to maintain targeted MAP <br/ ><br>2.Episodes of hypotension <br/ ><br>3.Adverse effects like intraoperative nausea / vomiting <br/ ><br>4. Short term neonatal outcome <br/ ><br>5. maternal blood loss <br/ ><br>Timepoint: 1. Total amount of vasopressor- before delivery of the baby <br/ ><br>2.Episodes of hypotension following administration of spinal anesthesia upto the time of uterine incision. <br/ ><br>3.Adverse effects like intraoperative nausea / vomiting - throughout the perioperative period <br/ ><br>4. Short term neonatal outcome: 1 and 5 minute Apgar score, <br/ ><br>5. maternal blood loss - intraoperative period