PROLONGED FASTING-INDUCED SKELETAL MUSCLE LIPID ACCUMULATION AND INSULIN RESISTANCE: pathological response or physiological adaptation?

Completed

• Conditions: diabetes; type 2 diabetes mellitus; 10018424

• Registration Number: NL-OMON30812
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

• Male sex
• Age 18-35 years
• BMI <25 kg/m2
• Sedentary
• healthy
• Stable dietary habits
• No (first or second-degree) family member with diagnosed type 2 diabetes

Exclusion Criteria

• Female sex
• Unstable body weight (weight gain or loss > 3 kg in the past three months)
• Participation in a regular exercise training program during the last year before the start of the study
• Any medical condition requiring treatment and/or medication use
• abuse of drugs and/or alcohol
• participation in another biomedical study within 1 month before the first screening visit

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameter is the difference in lipid accumulation and insulin<br /><br>sensitivity after prolonged fasting compared to the control trial. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>As secondary endpoints differences in lipid peroxidation, mitochondrial fatty<br /><br>acid export and mitochondrial damage between trials are considered.</p><br>