The Impact of Propofol and Ketamine on Cardiovascular Collapse During Induction for Intubation

Recruiting

• Conditions: Cardiovascular Collapse; Intubation Complication; Anaesthetic Complication Cardiac

• Registration Number: NCT06750939
• Lead Sponsor: Kocaeli City Hospital

Brief Summary

This prospective observational study evaluates the impact of propofol and ketamine on the risk of cardiovascular collapse during induction for endotracheal intubation in critically ill patients. Induction agents play a crucial role in managing hemodynamic stability, particularly in this vulnerable population. Propofol, known for its vasodilatory and myocardial depressant effects, has been associated with significant hypotension during induction. Conversely, ketamine, with its sympathomimetic properties, is often considered a safer alternative for hemodynamic stability.

In addition to comparing the incidence of cardiovascular collapse-defined as severe hypotension or cardiac arrest-this study examines the relationship between these induction agents and shock indices, including systolic shock index, diastolic shock index, age-adjusted shock index, and modified shock index. These parameters will provide a more detailed understanding of the hemodynamic effects of each agent and their clinical implications. The findings aim to guide induction agent selection to optimize outcomes in critically ill patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-07-15
• Status Verified: 2024-12
• Study First Submitted: 2024-12-05
• Study First Submitted QC: 2024-12-25
• Study First Posted: 2024-12-27
• Last Update Submitted: 2025-03-14
• Last Update Posted: 2025-03-19
• Primary Completion: 2025-04-01
• Study Completion: 2025-04-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 128

Inclusion Criteria

• Patients aged over 18 years
• Patients admitted to the intensive care unit (ICU) who undergo endotracheal intubation during their ICU stay will be included.

Exclusion Criteria

• Patients who did not provide consent to participate in the study
• Patients intubated due to cardiac arrest
• Patients intubated outside the intensive care unit

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
cardiovascular collapse	The occurrence of any of the above-mentioned events within the first 30 minutes following the initiation of the intervention will be considered as cardiovascular collapse.	* At least one documented episode of SpO₂ \< 80%, ensuring accuracy of measurement.; * At least one episode of systolic arterial blood pressure (SAB) \< 65 mmHg.; * SAB \< 90 mmHg sustained for a duration of 30 minutes.; * Initiation of norepinephrine therapy.; * Escalation of pre-existing norepinephrine infusion dose.; * Administration of \>15 mL/kg crystalloid fluids to achieve SAB \> 90 mmHg.; * Occurrence of cardiac arrest.

Trial Locations

Locations (1)

Kocaeli City Hospital; 🇹🇷 Kocaeli, Turkey