The Dutch famine birth cohort study: consequences of a suboptimal start in life

Completed

• Conditions: 10082206; veroudering incl cognitieve achteruitgang; ageing; 10018424

• Registration Number: NL-OMON35232
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 500

Inclusion Criteria

men and women born as term singletons around the time of the Dutch famine in the Wilhelmina Gasthuis, Amsterdan, the Netherlands, between 1 november 1943 and 28 february 1947

Exclusion Criteria

na

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- cognitive decline<br /><br>- incidence of white matter hyperintensities and cerebral microbleeds<br /><br>- cerebrovascular function<br /><br>- endothelial function<br /><br>- incidence of stroke<br /><br>- incidence of fractures<br /><br>- grip strength and physical performance<br /><br>- visual acuity<br /><br>- incidence of cataract operations<br /><br>- hearing<br /><br>- mortality.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>cerebrovascular function<br /><br>- cellular ageing (quantified by telomere length)<br /><br>- oxidative stress (quantified by a comet assay)<br /><br>basal inflammation (quantified by the inflammatory factors C-reactive protein<br /><br>(CRP) and total leukocyte count).</p><br>