Early diagnosis and early intervention by alendronate of glucocorticoid-induced osteoporosis in patients who are initially treated with glucocorticoid

Not Applicable

Recruiting

• Conditions: Connective tissue diseases

• Registration Number: JPRN-UMIN000002457
• Lead Sponsor: niversity of Occupational and Environmental Health, Japan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-09-06
• Study Completion: 2010-09-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 120

Inclusion Criteria

Not provided

Exclusion Criteria

1) female who are pregnant 2) male 3) patients who are already diagnosed as osteoporosis 4) patients who are already treated with glucocorticoid 5) patients who are already treated with bisphosphonate 6) patients diagnosed as esophageal narrowing or esophageal achalasia 7) patients who cannot stand or sit for more than 30 minutes 8) patients sensitive to bisphosphonates 9) patients with hypocalcemia 10) patients who are not appropriate to the study by a doctor's judgement

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1) Changes of bone metabolism markers at one week after the initiation of glucocorticoid therapy 2) Changes of bone metabolism at six months after the early intervention by alendronate in patients initially treated with glucocorticoid

Secondary Outcome Measures

Name	Time	Method
1) Change of bone metabolism markers at 6 months after the initiation of glucocorticoid therapy 2) Correlation of the changes of bone markers at one week after the treatment with the changes of bone metabolism at six months after the treatement