Analysis of Protein Expression in Serum of KOA Subjects

Not Applicable

Recruiting

• Conditions: Knee Osteoarthritis
• Interventions: Device: Micro-Western Array

• Registration Number: NCT06553313
• Lead Sponsor: China Medical University Hospital

Brief Summary

In the previous study "Using omics technology to explore the mechanism of acupuncture treatment of different acupoints of knee osteoarthritis: a randomized controlled trial (CMUH109-REC3-113)", we found that acupuncture for knee osteoarthritis(KOA) significantly reduces inflammation, apoptosis, and metabolism-related serum protein profiles. However, due to the lack of serum protein data from the control group, it is impossible to establish standard values for comparison. To analyze the protein expression in the serum of KOA control group subjects, we also measured the spectral energy values of the radial artery pulse wave obtained from the pulse sphygmograph and the meridian energy values obtained from Ryodoraku. The results obtained can be compared with previous studies, thus this experiment was designed.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-08
• Study Start: 2024-08-04
• Study First Submitted: 2024-08-04
• Study First Submitted QC: 2024-08-11
• Last Update Submitted: 2024-08-11
• Study First Posted: 2024-08-14
• Last Update Posted: 2024-08-14
• Primary Completion: 2025-07-23
• Study Completion: 2025-07-23

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Adults over 50 years old without knee pain

Exclusion Criteria

1. Clinical diagnosis of knee osteoarthritis
2. Taking anti-inflammatory and analgesic drugs in the past month
3. Taking blood-lipid-lowering drugs or health foods in the past month
4. Received any acupuncture treatment in the past 3 weeks

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
the control group of knee arthritis	Micro-Western Array	Monitoring the stability of protein expression, pulse wave and meridian energy in the serum of the KOA control group (participants without knee pain).

Primary Outcome Measures

Name	Time	Method
Micro-Western Array and Enzyme-linked immunosorbent assay	the first and the fifth weeks	Obtaining the serum protein content value

Secondary Outcome Measures

Name	Time	Method
pulse sphygmograph and Ryodoraku	the first and the fifth weeks	the energy measurement of pulse and meridians

Trial Locations

Locations (1)

China Medical University; 🇨🇳 Taichung, Taiwan