Ringer lactate and isotonic bicarbonate combination therapy versus ringer lactate therapy in treatment of burns patients

Phase 2

• Conditions: Health Condition 1: T31- Burns classified according to extent of body surface involved

• Registration Number: CTRI/2023/10/058364
• Lead Sponsor: All India Institute of Medical Sciences New Delhi

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 24 June 2024

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1) Adult patients >15 years

2) > 15 % flame/electric/scald/chemical (2nd and 3rd degree) burns

3) Time elapsed since burns not > 12 hrs

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Exclusion Criteria

1) < 15 years of age

2) < 15% TBSA burns

3) Index presentation > 12 hours

4) Pregnant patients

5) Known comorbidities like COPD, CKD, CLD and CHF

6) Who received fluids other than RL and isotonic bicarbonate prior to admission

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
actate clearanceTimepoint: 24 hours

Secondary Outcome Measures

Name	Time	Method
Base excess at 24 hours <br/ ><br>pH, pCO2, HCO3 values at 24 hours <br/ ><br>Hematocrit, serum osmolality & MCV values at admission & 24 hours <br/ ><br>SOFA scores at 24 hours, 48 hours & day 7 <br/ ><br>Mortality at day 7 <br/ ><br>24hr urine output <br/ ><br>Incidence & severity of AKI (KDIGO criteria) till day 7 <br/ ><br>Requirement of RRT till day 7 <br/ ><br>Duration of vasopressor therapy till day 7 <br/ ><br>Sugar values & cumulative insulin dose at 24 hours <br/ ><br>Serum potassium & ionized calcium at 24 hours <br/ ><br>Timepoint: 7 days