Mild intermittent hypoxia and metabolism
Recruiting
- Conditions
- Obesity, Insulin resistance, Adipose tissue, Skeletal muscle, Inflammation, Metabolism(in dutch: Obesitas, Insulineresistentie, Vetweefsel, Skeletspier, Ontsteking, Stofwisseling)
- Registration Number
- NL-OMON29164
- Lead Sponsor
- Maastricht University Medical Centre+
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
1. Male sex
2. Age 35-65 yrs
Exclusion Criteria
1. Cardiovascular disease
2. Type 2 diabetes mellitus
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Peripheral insulin sensitivity<br>(Glucose infusion rate during the steady-state of the high-step of a two-step hyperinsulinemic-euglycemic clamp)
- Secondary Outcome Measures
Name Time Method - oxygen saturation (SpO2, %)<br /><br>- adipose tissue oxygen tension<br /><br>- skeletal muscle oxygen tension<br /><br>- hepatic insulin sensitivity<br /><br>- adipose tissue insulin sensitivity<br /><br>- energy expenditure<br /><br>- fat and carbohydrate oxidation<br /><br>- plasma metabolite levels<br /><br>- systemic inflammatory markers<br /><br>- blood pressure and heart rate<br /><br>- body weight<br /><br>- hunger and satiety (VAS-scores)<br /><br>- adipose tissue gene/protein expression<br /><br>- skeletal muscle gene/protein expression<br /><br>- ex vivo skeletal muscle mitochondrial function