Impact of Implantation of an LAA Occluder on ANP and BNP Level and Quality of Life

Completed

• Conditions: Atrial Fibrillation

• Registration Number: NCT03085667
• Lead Sponsor: University of Leipzig

Brief Summary

Closure of the LAA by several devices is a alternative therapy to oral anticoagulation in patients with Atrail fibrillation. Nothing is known about the acute influence of a device closure of the LAA on the secretion of ANB nad BNP hormones. Therefore aim of our study is to measure ANB and BNP levvels before and after Implantation of an LAA closure device.

Detailed Description

ANB and BNP levels are measured before, directly after and late after 24 h in central or periphereal venous blood from patients undergoing interventional LAA closure.

Study Timeline

• Study Start: 2011-01
• Primary Completion: 2015-01
• Study Completion: 2015-12
• Study First Submitted: 2016-10-25
• Study First Submitted QC: 2017-03-14
• Study First Posted: 2017-03-21
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-04
• Last Update Posted: 2020-03-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• patients undergoing LAA closure

Exclusion Criteria

• none

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change from baseline atrial natriuretic Peptide (ANP)	24 h post intervention	comparison of ANP level pre and post intervention

Trial Locations

Locations (1)

Heart Center Leipzig- University Leipzig; 🇩🇪 Leipzig, Germany