Use of Laser Assisted New Attachment Procedure and Low Level Laser Therapy for Periodontitis Patients
- Conditions
- Periodontitis
- Registration Number
- NCT04694222
- Lead Sponsor
- Izmir Katip Celebi University
- Brief Summary
In this study, it is evaluated the effects of laser assisted new attachment procedure (LANAP) and low level laser therapy (LLLT) and on clinical, biochemical and radiographic parameters in addition to non-surgical periodontal treatment (NSPT).
- Detailed Description
The study was designed as a randomized-controlled, single-blind and parallel design consisting of 80 patients with chronic periodontitis. Study consists of 4 groups, with 20 patients in each group. Group 1 received only NSPT, Group 2 received NSPT+LANAP, Group 3 received NSPT+LLLT, and Group 4 received NSPT+LANAP+LLLT. Clinical measurements of patients and gingival crevicular fluid (GCF) were taken before treatment and after 1 and 3 months. In GCF, interleukin-1beta, interleukin-10 and vascular endothelial growth factor were analyzed. Standard periapical radiographs were taken for radiographic measurements.
In moderate (4-6 mm) and deep pockets (7 mm and above), it was found that all groups treated with laser significantly decrease pocket depth (PD) and clinic attachment level (CAL) compared to Group 1. Group 3 caused significantly less gingival recession than all other groups. There was no statistical difference between the groups in biochemical markers. Radiographic analysis revealed that only Group 2 achieved significant bone filling compared to Group 1.
Bot LANAP and LLLT application in the deep pockets provide an additional contribution to NSPT. It has been found that LLLT administration leads to decrease in PD by creating a minimum recession.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 89
- periodontitis of periodontal stage II, III, or IV with grades B
- with at least 12 teeth in the mouth and had ≥4 teeth but not all of them in the same quadrant
- with Probing depth of ≥5 mm, Clinical attachment level of ≥4 mm
- radiographic evidence of alveolar bone loss
- smoking
- pregnancy and lactation
- using antibiotics in the last 6 months and anti-inflammatory drugs in the last 3rd months,
- having the systemic disease and the use of the drug that will affect the periodontal condition, having restoration of the adjacent tooth to be collected gingival crevicular fluid
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Clinical attachment level gain 3 month The clinical attachment level is determined by measuring the distance from the cemento-enamel junction to the gingival margin and adding the pocket depth to it.
- Secondary Outcome Measures
Name Time Method Radiographic bone fill 3 Month The effects of treatments on bone loss were evaluated by making some measurements on periapical radiography.
Plaque index 3 Month This index measures the thickness of plaque on gingival one third
Interleukin-1beta 3 Month IL-1 is a protein produced mainly by monocytes and macrophages as a polyclonal activator.
Gingival index 3 Month For assessing severity of gingivitis, and its location by examining qualitative changes of gingival tissues
Probing depth 3 Month It is determined by measuring the distance from the gingival margin to the pocket base
vascular endothelial growth factor (VEGF) 3 Month VEGF is a glycoprotein molecule that is a potential stimulator of angiogenesis.
Bleeding on probing 3 Month In this index, probing is performed by gently walking around the pocket and bleeding is evaluated. As a result of probing, evaluation is made by looking at the presence or absence of bleeding in the gingiva.
Interleukin-10 3 Month IL-10 is an 18 kilodalton (KD) cytokine with a wide variety of (pleiotropic) effects.
Trial Locations
- Locations (1)
Katip Celebi University
🇹🇷Izmir, Turkey