The prospective observational study to assess the association of peri-operative managements with the incidence of postoperative complications in cardiac surgery patients
Not Applicable
- Conditions
- cardiac surgery/Major vascular surgery
- Registration Number
- JPRN-UMIN000014991
- Lead Sponsor
- Kobe University Hospital, Anesthesiology Department
- Brief Summary
We obtained perioperative free hemoglobin(fHb) and haptoglobin(Hp) levels during the study period in adult patients undergoing valvular and aortic surgery requiring cardiopulmonary bypass (CPB). The increase of fHb level and decrease of Hp level had independent associations with post operative AKI. And, we estimated cutoff values were 0.06g/dL at CPB1(1hr after CPB) , 0.12g/dL as preoperative maximum fHb(maxfHb), respectively.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Not provided
Exclusion Criteria
Patients with chronic renal dysfunction (serum creatinine is equal or more than 2mg/dL) Patients who require hemodialysis. patients with any conditions which cause hemolysis.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The incidence of acute kidney injury (RIFLE criteria)
- Secondary Outcome Measures
Name Time Method The duration of postoperative hospital stay The duration of postoperative ICU stay The duration required postoperative mechanical ventilatory support The presence of organ failures (SOFA score) The presence of postoperative respiratory complications associated with mechanical ventilation (VAC criteria) The incidence of postoperative delirium (CAM-ICU) The strength of oxidative stress