Laryngeal Adaptation for Speech and Swallowing
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Laryngeal Adaptation in Swallowing
研究概览
简要总结
This study will test laryngeal adaptation in speech and swallowing function in healthy adults, in patients with cerebral stroke, and in patients with spinocerebellar ataxia type 6. The findings from this proposal will be the first step toward implementing rehabilitation techniques that help patients to prevent speech and swallowing errors before they occur.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All stroke and ataxia
- •DNA diagnosis of SCA6 and phenotype consistent with the DNA diagnosis
- •No recessive, X-linked or mitochondrial
- •Bilateral or unilateral middle cerebral artery (MCA) stroke
- •No structural abnormalities (i.e. nodules)
- •Dysphagia involving laryngeal dysfunction
- •Stroke and ataxia with speech and swallowing disorders
- •no structural abnormalities
- •dysphagia involving laryngeal dysfunction
排除标准
- •Montreal Cognitive Assess. <24
- •Moderate to severe hearing loss
- •Barium allergy
- •Other confounding speech disorder (i.e. stuttering)
- •Chemo-radiation, surgical head and neck treatment
- •Smoking Hx in the past 5 yrs or >5 years at any one time
- •Twenty one years of age or older
- •Breathing disorders or diseases
结局指标
主要结局
Laryngeal Adaptation in Swallowing
时间窗: Day 1
To differentiate laryngeal adaptation among cerebral stroke, SCA6, and healthy controls when swallowing is perturbed with neck surface electrical stimulation to restrict laryngeal elevation.
Laryngeal Adaptation in Speech
时间窗: Day 1
To differentiate laryngeal adaptation during speech among cerebral stroke, SCA6, and healthy controls when vocal loudness is perturbed with expiratory loading.
次要结局
未报告次要终点