oninvasive cardiac output monitoring to optimise therapy for patients with poorly controlled hypertension: a randomised controlled trial

Not Applicable

• Conditions: Hypertension; Cardiovascular - Hypertension

• Registration Number: ACTRN12611001289909
• Lead Sponsor: The Chinese University of Hong Kong

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-12-16
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 202

Inclusion Criteria

Patients aged 18 or above who attend the Emegency Department with mean systolic blood pressure > or =160mmHg or diastolic blood pressure >or =100mmHg at two or more blood pressure measurements at least 20 minutes apart, and on two separate occasions (i.e. 2 different calendar days within a 2-week period).

Exclusion Criteria

1. The patient is pregnant or lactating.

2.The patient is unable to lie supine for USCOM assessment (e.g. due to shortness of breath, severe back pain, oxygen therapy, deformities or pain).

3.The patient is confused, psychiatrically disturbed, or unable to answer questions or communicate.

4.The patient is likely to be admitted to hospital (except admission to the Emergency Medicine Ward).

5. Hypertensive emergencies (e.g. acute stroke, acute coronary syndromes, acute left ventricular failure, acute aortic dissection, hypertensive encephalopathy.)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean reduction of systolic BP from baseline<br><br>Blood pressure measurements<br>Blood pressure and heart rate will be measured in the right arm with an appropriately sized cuff using a standard oscillometric device.[Weeks 6, 12, 18 and 24]

Secondary Outcome Measures

Name	Time	Method
Mean reduction of diastolic BP <br><br>Blood pressure and heart rate will be measured in the right arm with an appropriately sized cuff using a standard oscillometric device.[Weeks 6, 12, 18 and 24];Proportion of patients achieving target BP (<140/90 mmHg)<br><br>Blood pressure and heart rate will be measured in the right arm with an appropriately sized cuff using a standard oscillometric device.[Weeks 6, 12, 18 and 24];Proportion of patients achieving normalization of haemodynamic parameters.<br><br>Transcutaneous Doppler ultrasound haemodynamic measurements<br>The transducer of the machine is placed on the patient's chest in either the left parasternal position to measure trans-pulmonary blood flow, or the suprasternal position to measure trans-aortic blood flow. <br><br>The procedure will take 5 - 10 minutes to complete and is noninvasive.[Weeks 2, 6, 12, 18 and 24]