Luteal Phase Supplementation With Recombinant LH After GnRh Agonist Oocytes Triggering in Women at Risk of OHSS
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Pregnancy Rate and Implantation Rate
研究概览
简要总结
The purpose of this study is to prove that luteal phase supplementation with recombinant LH can solve the luteal phase deficiency after Gnrh agonist oocytes triggering in women at risk of OHSS
详细描述
The investigators enrolled patients, undergoing controlled ovarian stimulation for an IVF/ICSI cycles, who on the day of oocytes triggering were at risk of OHSS.
These patients had an estradiol > 4000 pg/ml and more than 24 follicles with a diameter greater than 12 mm.
The investigators used 0,2 mg of triptorelin for the oocytes triggering and supplemented the luteal phase with recombinant LH at a dose of 75 UI twice/day for 10 days and vaginal gel progesterone and oral oestradiol for 14 days The investigators measured bhCG at 14 days from the pick up. In case of positive bhCG we have defined the IVF/ICSI outcome: Pregnancy Rate and Implantation Rate.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 43 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •patients with an oestradiol > 4000 pg/ml on the oocytes triggering day
- •patient with more than 24 follicles of diameter greater than 12 mm on the oocytes triggering day
排除标准
- •patients with no risk of OHSS on the oocytes triggering day
- •patients with an oestradiol < 4000 pg/ml on the oocytes triggering day
- •patient with less than 24 follicles of diameter greater than 12 mm on the oocytes triggering day
研究组 & 干预措施
Patients at risk of OHSS
Patients at risk of OHSS on the oocytes triggering day with an oestradiol > 4000pg/ml or a number of follicles greater than 24 of a diameter greater than 12 mm
干预措施: recombinant LH (Drug)
结局指标
主要结局
Pregnancy Rate and Implantation Rate
时间窗: From 14 days after the pick up to six weeks of gestation
We measured bhCG after 14 days from the pick up. In presence of a positive value of bhCG we evaluated IVF/ICSI outcome through the pregnancy rate and implantation rate.
次要结局
- Ealy and Late Ovarian Hyperstimulation Syndrome(From 9 days after pick up to 12 weeks of gestation)
研究者
Assunta Iuliano, MD
MD, PhD
San Carlo Public Hospital, Potenza, Italy