Perceptual Learning Treatment for Amblyopia

Not Applicable

Completed

• Conditions: Amblyopia
• Interventions: Other: Occlusion therapy; Other: Acuity training

• Registration Number: NCT03788031
• Lead Sponsor: The Hong Kong Polytechnic University

Brief Summary

Objectives. To develop a new treatment for amblyopia using a perceptual learning approach.

Hypothesis to be tested. Our proposed experiments are designed to investigate whether practicing a grating detection task can improve vision in patients with amblyopia.

Design and subjects. A total of 36 patients with amblyopia will be randomized allocated into two intervention groups: Group 1, perceptual learning therapy. Group 2, occlusion therapy. A control group comprising of 18 subjects with normal vision will be recruited for comparison. A battery of tests will be used to assess a range of visual functions before and after the treatment intervention.

Study instruments. Grating acuity testing system

Interventions. We have established a clinical protocol for acuity training. On each trial, a properly oriented stimulus will be presented randomly at one of the four locations on a flat monitor screen. The visual task is to indicate the location of the stimulus. Participants will be required to undertake 20 one-hour sessions of training.

Main outcome measures. Resolution acuity, visual acuity, contrast sensitivity function

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-12-11
• Study First Submitted QC: 2018-12-23
• Study First Posted: 2018-12-27
• Study Start: 2019-03-01
• Status Verified: 2021-08
• Primary Completion: 2022-12-31
• Study Completion: 2023-02-28
• Last Update Submitted: 2024-08-28
• Last Update Posted: 2024-08-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

• Visual acuity in the amblyopic eye: 20/25 or worse

Exclusion Criteria

• Manifest eye disease & nystagmus

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Occlusion therapy - Amblyopia	Occlusion therapy	Patching
Perceptual learning group - Amblyopia	Acuity training	Visual training
Perceptual learning group - Control	Acuity training	Visual training

Primary Outcome Measures

Name	Time	Method
Change of grating acuity	20 hours	Grating acuity tests the participants' ability to resolve fine details. This study measures the change of grating acuity after 20 hours of vision training.

Secondary Outcome Measures

Name	Time	Method
Change of visual acuity	20 hours	Visual acuity tests the participants' ability to resolve letters.This study measures the change of visual acuity after 20 hours of vision training.
Change of contrast sensitivity	20 hours	Contrast sensitivity reflects the participants' sensitivity to identify low contrast visual stimuli. This study measures the change of contrast sensitivity after 20 hours of vision training.
Change of stereopsis	20 hours	Visual acuity tests the 3-D perception. This study measures the change of stereopsis after 20 hours of vision training.

Trial Locations

Locations (1)

Optometry Research Clinic; 🇭🇰 Hong Kong, Hong Kong