NL-OMON55149招募中4 期
Treatment of vascular stiffness in patients with autosomal dominant polycystic kidney disease - TRAMPOLINE
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 54
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Adults with ADPKD diagnosis based on Ravine criteria and/or a documented Pkd
- •1 or 2 mutation
- •- CKD-EPI eGFR >=60 ml/min/1.73m2
- •- Ability to provide informed consent
排除标准
- •- Uncontrolled hypertension, defined as an office blood pressure of >=160/ >=90
- •mmHg with or without antihypertensive treatment
- •- Concomitant use of >=3 antihypertensive medications
- •- When antihypertensive treatment is prescribed for any other treatment
- •indication than hypertension (e.g. cardia arrhythmia)
- •- Serum potassium levels >5.5 mmol/L (measured within last 6 months)
- •- History of liver disease (excluding liver cysts due to ADPKD)
- •- History of heart failure (cardiac ejection fraction < 35%) or cardiac
- •- History of diabetes mellitus
- •- Active infection or antibiotic therapy
- •- Immunosuppressive therapy within the last year
- •- Concomitant use of drugs that could influence blood pressure and/or disease
- •progression (Tolvaptan/non-steroidal anti-inflammatory drugs
- •(NSAIDs)/chemotherapy), excluding <3 antihypertensive drugs
- •- Actual pregnancy or unwillingness to adhere to reproductive precautions
- •during the duration of the study
研究者
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