CTIS2024-512544-27-00进行中（未招募）1 期
Treatment of vascular stiffness in patients with autosomal dominant polycystic kidney disease
适应症
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 54
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 65+（—）
- 性别
- All
入选标准
- •Adults with typical ADPKD diagnosed based on Ravine criteria and/or a documented Pkd 1 or 2 mutation, CKD-EPI eGFR =60 ml/min/1.73m2, Ability to provide informed consent
排除标准
- •Uncontrolled hypertension, defined as an office blood pressure of =160/ =90 mmHg with or without antihypertensive treatment, Concomitant use of drugs that could influence blood pressure and/or disease progression (Tolvaptan/non-steroidal anti-inflammatory drugs (NSAIDs)/chemotherapy), excluding £ 2 antihypertensive drugs, Actual pregnancy or unwillingness to adhere to reproductive precautions during the duration of the study, Concomitant use of = 3 antihypertensive medications, When antihypertensive treatment is prescribed for any other treatment indication than hypertension (e.g. cardia arrhythmia), Serum potassium levels >5.5 mmol/L (measured within last 6 months), History of liver disease (excluding liver cysts due to ADPKD), History of heart failure (cardiac ejection fraction < 35%) or cardiac arrhythmia, History of diabetes mellitus, Active infection or antibiotic therapy, Immunosuppressive therapy within the last year
研究者
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