Effects of Berries on Post-meal Blood Sugar

Not Applicable

Completed

• Conditions: Blood Glucose, Postprandial; Blood Insulin, Postprandial; Hyperglycemia
• Interventions: Other: Berries; Other: No berries

• Registration Number: NCT01580150
• Lead Sponsor: Marjukka Kolehmainen

Brief Summary

The purpose of this study is to investigate whether berries are effective in lowering blood glucose and insulin responses to meals containing starch or sucrose.

Detailed Description

Berries are rich sources of various polyphenols which may be beneficial in the regulation of blood glucose. In vitro and animal studies have shown that polyphenols and polyphenol-rich extracts of foods, including berries, may inhibit digestion and absorption of carbohydrates and thereby suppress postprandial glycemia. However, current evidence on the effects of berries on postprandial glycemic responses in humans is limited.

The purpose of this study is to investigate the effects of berries on postprandial glycemic responses (blood glucose and insulin) to starch or sucrose in healthy subjects. It consists of five substudies each of which includes 2-4 meals with different berry species typically consumed in Finland and a reference meal without berries. The following combinations of carbohydrates and berries are studied:

* Studies 1-2: white wheat bread (starch) is consumed with several berry species

* Study 3: white wheat bread or rye bread is consumed with a mixture of berries

* Study 4: sugar (sucrose) is consumed with berries and berry nectars

* Study 5: a sugar-sweetened bakery product (starch + sucrose) is consumed with berries and berry nectar.

Study Timeline

• Study Start: 2009-11
• Primary Completion: 2012-01
• Study Completion: 2012-01
• Status Verified: 2012-04
• Study First Submitted: 2012-04-16
• Study First Submitted QC: 2012-04-16
• Last Update Submitted: 2012-04-16
• Study First Posted: 2012-04-18
• Last Update Posted: 2012-04-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

• BMI 20-28 kg/m2
• normal fasting plasma glucose

Exclusion Criteria

• Smoking
• Diabetes or other chronic disease
• Antibiotic medication within the past 3 months
• Blood donation within the past month

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Berry meal	Berries	Carbohydrate meals with berries
Reference meal	No berries	Carbohydrate meals without berries

Primary Outcome Measures

Name	Time	Method
Plasma glucose	0, 15, 30, 45, 60, 90, 120 minutes post-meal
Plasma insulin	0, 15, 30, 45, 60, 90, 120 minutes post-meal

Secondary Outcome Measures

Name	Time	Method
Plasma free fatty acids	0, 15, 30, 45, 60, 90, 120 minutes post-meal

Trial Locations

Locations (1)

University of Eastern Finland; 🇫🇮 Kuopio, Finland