Skin Sympathetic Nerve Activity and Sympathetic Tone

• Conditions: Nerve; Disorder, Sympathetic; Healthy

• Registration Number: NCT03243448
• Lead Sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital

Brief Summary

There are many sympathetic hyperactivity diseases in the investigators' clinical practice. However, the conventional method to measure the sympathetic nerve activity had many limitations such as clinical application, data interpretation and even therapeutic manipulation. Therefore the investigators would like to develop a non-invasive method to record the sympathetic nerve activity in the investigators' study that can help gathering the sympathetic nerve activity easily in the investigators' daily clinical situation. By the determination of sympathetic nerve activity status, the health caregiver can understand the disease more.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-08-01
• Study First Submitted: 2017-07-17
• Study First Submitted QC: 2017-08-03
• Study First Posted: 2017-08-09
• Status Verified: 2023-10
• Last Update Submitted: 2023-10-02
• Last Update Posted: 2023-10-04
• Primary Completion: 2026-07-31
• Study Completion: 2026-07-31

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Sympathetic hyperactivity diseases included: hypertension, heart failure atherosclerotic diseases, arrhythmias, cardiomyopathy, pulmonary hypertension, chronic obstructive pulmonary disease, sleep apnea, pulmonary embolism, hepatitis, liver cirrhosis, hepatopulmonary syndrome, hepatorenal syndrome, renal failure, nephritis, irritable bowel syndrome.
• Healthy Volunteers

Exclusion Criteria

• Pregnant

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Skin Sympathetic Nerve Activity	12 hours	The Sympathetic Nerve Activity Recording from the skin of the subjects in the day time.

Secondary Outcome Measures

Name	Time	Method
ventricular arrhythmia	24 to 72 hours	The electrocardiogram recording from the telemetry.
Mortality	1 to 12 months	The mortality will be accessed by the chart review and telephone access
Morbidity	1 to 12 months	The morbidity will be accessed by the chart review and telephone access