Sympathetic Innervation of the Heart and Cardiac Resynchronization Therapy(CRT)

Withdrawn

• Conditions: Chronic Heart Failure; Sympathetic Innervation

• Registration Number: NCT00567645
• Lead Sponsor: University Medical Center Groningen

Brief Summary

The purpose of this study is to assess whether baseline sympathetic innervation in patients with chronic heart failure (CHF) is predictive for response to cardiac resynchronization therapy (CRT). And to assess whether response to CRT coincides with restoration of regional sympathetic innervation.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-07
• Study First Submitted: 2007-12-04
• Study First Submitted QC: 2007-12-04
• Study First Posted: 2007-12-05
• Status Verified: 2016-05
• Last Update Submitted: 2016-05-12
• Last Update Posted: 2016-05-13

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Indication for CRT
• Stable optimal medication
• Non ischemic cardiomyopathy

Exclusion Criteria

• Age less then 18 years
• Previous CRT
• Clinically relevant valvular heart disease or coronary artery disease
• Acute or chronic infection
• Untreated clinical hypo- or hyperthyroidism or < 3 months euthyroidism
• Uncontrolled hypertension, defined as a systolic blood pressure > 160 mm Hg and/or a diastolic blood pressure > 95 mm Hg
• A concurrent medical condition (i.e. alcohol or drug abuse or a severe progressive extra cardiac disease or M. Parkinson) or is unlikely to comply with the protocol
• Participation to a previous protocol involving radioactivity in the past year
• Pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
sympathetic innervation in patients with chronic heart failure (CHF)	6 months

Secondary Outcome Measures

Name	Time	Method
NYHA class Echocardiographic parameters: LVEDD, LVESD, LVEF, LVESV,IVMD, and septal to lateral delay Hospitalization for heart failure Maximal oxygen consumption NT pro-BNP changes	6 months

Trial Locations

Locations (1)

University Medical Center Groningen; 🇳🇱 Groningen, Netherlands