Neural Correlates of Language Control in Bilinguals. Functional MRI and Stimulation Mapping Data in Awake Surgery. (NEUROSWITCH)
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Bilingualism
- Sponsor
- University Hospital, Toulouse
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Brain activity
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
For bilingual and multilingual patients, brain activation and Electric Stimulation Mapping studies have shown that different languages may be localized, at least partially, in distinct microanatomical systems located within the same gross anatomical areas.
The present investigation involves both types of healthy bilinguals with carefully controlled proficiency levels, as well as bilingual patients suffering from low-grade glioma.
Functional magnetic resonance imaging data will be collected while the participants perform a picture naming task in blocked conditions for both languages (either English or French) or in switch condition (English and French). A stimulation mapping study will be conducted in the patients during awake surgery with the same tasks.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Bilingual patients with a pathology indicating an intervention in awake surgery (e.g. low-grade glioma)
- •At least C1-level of the CECR in both languages
- •At least 12 years of schooling (French BAC)
- •Right-handed (Edinburgh test, 1971)
- •Performance indicator Eastern Cooperative Oncology Group 0-2 (cf. annexe)
- •Life expectation \> 6 month
- •Affiliated to social insurance
- •Having given informed consent
- •Healthy volunteers:
- •French-English or English-French bilinguals with at least a C1 level (CECR) in both languages
Exclusion Criteria
- •Contra-indication for MRI
- •Left-handed or ambidexter (less than +80 at the Edinburgh test - 1971)
- •Mini-Mental State Examination \<26
- •Patient who cannot respect the procedures, visits, exams described in the protocol
- •Any other medical or psychiatric affection which renders inclusion of the patient to the study inappropriate as judged by the principal investigator
- •Healthy volunteers:
- •Contra-indication for MRI
- •Mini-Mental State Examination \< 26
- •Age of acquisition of one of the language between 3 and 10 years
Outcomes
Primary Outcomes
Brain activity
Time Frame: 24 hours
The primary judgment criteria is brain activity as measured by functional magnetic resonance imaging : * In blocked vs. switched naming in control subjects * In switched naming in early vs. late bilingual subjects * In blocked vs. switched naming in early vs. late bilingual subjects
Secondary Outcomes
- Brain activity(24 hours)