Evaluation of the relationship between subgingival and intestinal microbiomes in patients with periodontal diseases - cross-sectional study

niversidade de São Paulo0 个研究点开始时间: 2024年8月1日最近更新: 2024年8月19日

适应症

试验速览

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•All individuals must be systemically healthy; of either gender; at least 18 years old; have at least 15 natural teeth, excluding third molars and teeth indicated for extraction; and be willing to adhere to the study protocol. In the Periodontal Health group: absence of attachment loss and bone loss due to periodontitis; probing depth (PD) up to 3 mm at all sites and bleeding on probing (BOP) at no more than 10% of sites throughout the entire oral cavity. For the Gingivitis group: presence of generalized gingivitis, with more than 30% of the sites in the whole mouth showing BOP; all sites with PD up to 3 mm and absence of attachment loss and bone loss due to periodontitis. In the Periodontitis group: presence of generalized stage III periodontitis, grades B or C, with at least 30% of the teeth having at least one site with PD and Clinical Attachment Level (CAL) = 5 mm and BOP

•Use of antibiotics, probiotics, and/or prebiotics in the last six months; undergoing periodontal treatment in the last six months; continuous use of mouthwashes containing antimicrobial agents; long-term use of anti-inflammatory or immunosuppressive medication; any systemic involvement that may interfere with the onset and/or progression of periodontal diseases; chronic gastrointestinal diseases; extensive prosthetic involvement; need for antibiotic prophylaxis for routine dental procedures; smoking; pregnancy; lactation

发起方

niversidade de São Paulo