ebulized ketamine versus intravenous morphine for older adults with acute musculoskeletal pain in the emergency department: a randomized controlled trial

AVAMINDRADHIRAJ UNIVERSITY RESEARCH FUND0 个研究点目标入组 98 人开始时间: 2022年7月19日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•1.Patients aged 65 and older, who presented to the ED with the chief complaint of musculoskeletal pain within 7 days.
•2.Pain score of 5 or more on a 11-point numeric rating scale [0 (no pain) to 10 (most severe pain)].

•1.Patients who had hemodynamic instability which were defined as systolic blood pressure < 90 or > 180 mmHg, heart rate < 50 or > 150 beats/min , respiratory rate < 10 or > 30 breaths /min.
•2.Patients with comorbidities of coronary artery disease or congestive heart failure, psychological disorder or severe chronic obstructive pulmonary disease.
•3.Patient with chronic pain
•4.History of traumatic brain or eye injury.
•5.History of seizure or intracranial hypertension.
•6.History of morphine or ketamine allergy.
•7.History of opioid used within 8 hours (e.g. tramadol, fentanyl , morphine, codeine, pethidine, methadone) or unknown drug used.)
•8.History of alcohol or drug abuse.
•9.Actual body weight < 40 kilogram (kg) or > 115 kg.
•10.Creatinine clearance < 50 ml/min.
•11.Hepatic insufficiency.
•12.Patients who needed immediate surgical intervention.
•13.Patients with difficulty to communication (e.g. altered mental status, severe dementia (define by 6-items cognitive screening > 12), language barrier).

发起方

AVAMINDRADHIRAJ UNIVERSITY RESEARCH FUND