Esophageal motility disorders and gastroesophageal reflux in ventilated critically ill patients with different feeding tolerance: effect of prokinetics
- Conditions
- Esophageal dysmotility and gastroesophageal reflux in ventilated critically ill patientsDigestive System
- Registration Number
- ISRCTN14399966
- Lead Sponsor
- Charles University Faculty of Medicine in Pilsen
- Brief Summary
2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33557860/ results (added 10/02/2021)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 16
Critically ill patients
1. Informed consent signed by a close relative and retrospectively by the patient when his/her condition allows it
2. Age of 18 years and above
3. Mechanically ventilated critically ill patient
4. Inclusion within 24-48 hours after reaching the enteral nutrition target of 25 kcal/kg/day
5. Maximum stable dose of noradrenaline up to 0.2 µg/kg/min
6. Enteral nutrition via nasogastric tube
Control group
1. Signed informed consent
2. Age of 18 years and above
Critically ill patients:
1. History of previous surgery on upper gastrointestinal tract
2. Gastroesophageal reflux disease
3. Portal hypertension
4. Active gastrointestinal bleeding
5. When an acute diagnostic or treatment procedure outside the intensive care unit at the time of HRIM measurements is required
6. Epilepsy, severe CNS damage or other contraindication for metoclopramide administration
7. Coagulopathy with INR value above 2.5 and platelets below 30x10e9/L
8. Pregnancy
Control group
1. History of previous surgery on upper gastrointestinal tract
2. Diagnosed gastroesophageal reflux disease or symptoms thereof, esophageal varices, or other organic esophageal or gastric disorder
3. Use of chronic medication, other acute or chronic illness
4. Pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method