Effects of Exercise and 5-HTP on Cortisol Levels

Not Applicable

• Conditions: Plasma Cortisol
• Interventions: Dietary Supplement: Placebo; Dietary Supplement: 5-HTP

• Registration Number: NCT02187341
• Lead Sponsor: Benedictine University

Brief Summary

It has been shown that 5-HTP stimulates cortisol levels in plasma and saliva. Similarly, it has been shown that intense exercise stimulates an increase in plasma and salivary cortisol levels. The purpose of this study is to examine the combined effects of 5-HTP + intense exercise on plasma and salivary cortisol levels.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-06
• Status Verified: 2014-07
• Study First Submitted: 2014-07-02
• Study First Submitted QC: 2014-07-10
• Last Update Submitted: 2014-07-10
• Study First Posted: 2014-07-11
• Last Update Posted: 2014-07-11
• Primary Completion: 2015-12
• Study Completion: 2015-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Healthy men and women, not taking medication known to alter glucocorticoid metabolism

Exclusion Criteria

• Diabetes
• Obesity
• Hypertension
• Coronary artery disease
• Psychiatric disorders
• Any disease preventing them from participating in intense exercise
• Subjects taking medication known to interfere with glucocorticoid metabolism will be excluded

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	For these visit subjects will ingest placebo (Sugar pill) capsule 2 hours before reporting to the laboratory.
5-HTP	5-HTP	200 mg 5-HTP capsule will be ingested 2h prior to reporting to the laboratory.

Primary Outcome Measures

Name	Time	Method
Change in plasma cortisol from baseline to 20 minutes post	baseline, 20 min	Plasma cortisol will be assessed at baseline and 20 min post exercise and compared to baseline, and compared between treatments: 5-HTP vs placebo visit. The interventions are acute ( 1 dose, 1 day), for 5-HTP and for placebo, there is no follow up. The interventions are at least 1 week apart. For a given subject, the estimated time for study completion for the 2 treatments is 10 to 30 days

Secondary Outcome Measures

Name	Time	Method
Change in plasma cortisol from baseline to 5 minutes post	baseline, 5 minutes	Plasma cortisol will be assessed at baseline and 5 min post exercise and compared to baseline, and compared between treatments: 5-HTP vs placebo visit. The interventions are acute ( 1 dose, 1 day), for 5-HTP and for placebo, there is no follow up. The interventions are at least 1 week apart. For a given subject, the estimated time for study completion for the 2 treatments is 10 to 30 days

Trial Locations

Locations (1)

Benedictine University; 🇺🇸 Lisle, Illinois, United States