Comparing the Effectiveness of Two different Reversal Agents in Reversing the Neuromuscular Paralysis by Muscle Relaxant in patients undergoing surgery under General anesthesia

Phase 4

Conditions: Health Condition 1: O- Medical and Surgical

Registration Number: CTRI/2024/07/070359

Lead Sponsor: Pondicherry Institute of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1) Patients aged between 18 to 60yrs, Patients belonging to ASA class I and II

Exclusion Criteria

1) Significant kidney disease (stage 4 kidney disease or higher), Significant liver disease (aspartate aminotransferase [AST] or

alanine aminotransferase[ALT] more than twice the upper limit of normal), Emergency surgeries under general anaesthesia, Patients requiring post operative mechanical ventilation, Difficult airway, Pregnancy/Breastfeeding, Known case of neuromuscular disorder, Allergies to study drugs

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the incidence of post operative residual neuromuscular paralysis with <br/ ><br>sugammadex or neostigmine during vecuronium induced moderate neuromuscular blockade with Train of Four (TOF) monitoring in patients undergoing surgery under general anesthesiaTimepoint: 1 year

Secondary Outcome Measures

Name	Time	Method
To compare the baseline Forced expiratory volume (FEV1) and Peak expiratory flow <br/ ><br>rate (PEFR) values and post-operative Forced expiratory volume (FEV1) and Peak <br/ ><br>expiratory flow rate (PEFR) after arrival to Post anaesthesia care unit (PACU)Timepoint: 1 year;To compare the time from the start of administration of sugammadex or neostigmine to <br/ ><br>recovery of the Train of Four (TOF) ratio to 0.9Timepoint: 1 year;To record adverse events in both the groups until discharge from Post anaesthesia care unit (PACU)Timepoint: 1 year