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Role of dexmedetomidine(sedative and analgesic used in ICU) in postoperative heart rate and rhythm control in patients with valvular heart disease undergoing valve replacement surgery: A randomized double blind controlled study

Not Applicable
Completed
Conditions
Health Condition 1: null- Patients with rehumatic heart disease undergoing valve replacement surgery.
Registration Number
CTRI/2018/05/013741
Lead Sponsor
AIIMS New Delhi
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Completed
Sex
Not specified
Target Recruitment
56
Inclusion Criteria

1 patients suffering from rheumatic mitral valve disease with atrial fibrillation, scheduled for routine mitral valve replacement surgery.

Exclusion Criteria

1 Patients with HR of < 55/min

2 LA size >60mm

3 NYHA IV

4 Sick sinus rhythm

5 Atrioventricular block

6 Serum creatinine >200mmol/l

7 Elevated liver enzymes

8 Concomitant coronary artery disease

9 Moderate to severe LV dysfunction

10 Redo and emergency surgery

11 Patients on mechanical ventilation/ intra-aortic balloon pump

Study & Design

Study Type
Interventional
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Heart rate and rhythmTimepoint: Base line, just before onset of CPB, after aortic cross clamp release, after completion of surgery, at the time of extubation, at the time of shifting out of ICU.
Secondary Outcome Measures
NameTimeMethod
HR and rhythm at the time of shifting to the ward from ICU, duration of mechanical ventilation and ICU stay, and complications in consequence to AF if any.Timepoint: ICU shifting to shifting in post operative ward.
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