A feasibility study of fMRI-neurofeedback in Parkinson*s disease

Completed

• Conditions: 10028037; Parkinson's disease; Shaking palsy

• Registration Number: NL-OMON53752
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

- Diagnosis of Parkinson*s disease according to MDS clinical diagnostic
criteria (Postuma et al., 2015).
- Disease stage 1-3 according to the Hoehn and Yahr Scale

Exclusion Criteria

- Exclusion criteria for MRI (e.g., cardiac pacemaker, certain metallic
implants)
- History of psychotic disorder, bipolar disorder, or psychotic depression
- Current use of illegal drugs (any in the last four weeks)
- Current excessive alcohol consumption that interferes with daily functioning
- Advanced cognitive impairment (MoCA <24) or dementia

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The region of interest fMRI data will be analysed with the appropriate<br /><br>parametric tests for activation and general linear model analysis will be<br /><br>performed as implemented in the Brainvoyager software. This will assess<br /><br>neurofeedback performance and changes in brain activation over time.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Correlational analysis will be performed on demographic and clinical data (MoCA<br /><br>score) to assess association with neurofeedback performance.</p><br>