Realtime fMRI Neurofeedback in the Treatment of Alcohol Use Disorder

Not Applicable

Recruiting

Conditions: F10.2

Registration Number: DRKS00010253

Lead Sponsor: Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut für Seelische Gesundheit, Universität Heidelberg

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

Gender: Both, male and female
-Age: 18 and 65 years
-Normal or corrected to normal vision with best corrected visual acuity ( > 0,8, Landolt C rings)
-appropriate comprehension of the German language
-written informed consent
-Alcohol use disorder according to DSM-IV and ICD-10
-abstinent for 5-28 days at first assessment, finished alcohol detoxification

Exclusion Criteria

-Axis I mental disorders (SCID-I) during the last 12 months except (for patients) abuse and dependence of alcohol and
nicotine
-neurological disorders
-epilepsy
-exclusion criteria for MRT (pace maker, implanted metal or pregnancy)
-positive drug screening
-any current psychoactive medication for the last 3 days before study entry
-suicidal tendencies

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rate of relapse after neurofeedback training:<br>- follow-up contacts after 1, 2 (phone interview) and 3 months (interview in the clinic) after the completion of neurofeedback Training.<br>-Form 90 (Structured Assessment Interview<br>for Drinking and Related Behaviors)<br>- OCDS-G (Obsessive compulsive Drinking Scale)<br>- CAS-A (Craving-Automatized-Scale-Alcohol)<br>- AASE(Alcohol Abstinence Self-Efficacy Scale)<br>- AUQ (Alcohol Urge Questionnaire)<br>-breath test and blood test (at the beginning of the interview in den clinic, after 3 months of the last neurofeedback training)<br><br><br>

Secondary Outcome Measures

Name	Time	Method
Functional changes (activation and connectivity) in the brain over the sessions assessed with magnetic resonance Imaging.<br><br>Changes in alcohol craving during the sessions assessed by a visual analogue scale.<br><br>Predicitive power of magnetic resonance Imaging for learning neurofeedback and for the success of the intervention.<br><br>Differences in effectivity of the group-specific interventions.