The microbiome and the chance of recurrent venous thrombosis determined by the DASH-score (MIDAS-study)
Completed
- Conditions
- parodontitisdeep vein thrombosis10014523
- Registration Number
- NL-OMON47000
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 70
Inclusion Criteria
- 18 years of age or older
- First idiopathic or oral contraceptive use-associated deep vein thrombosis of the leg or idiopathic pulmonary embolism
- No further or other indication to continue anticoagulant therapy
- Understand spoken and written Norwegian or Dutch or English.
- Able to give written informed consent
Exclusion Criteria
- Liver failure
- Clinical active infection or auto-immune disease
- Pregnancy or puerperium
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Any differences between cases (DASH score >1) and controls (DASH <=1) in<br /><br>absolute bacterial load of the oral and gut microbiome, and b) abundance of<br /><br>certain phyli of the oral and gut microbiome. We shall also carry out this<br /><br>analysis with patient who did suffer a venous thrombotic recurrence (cases)<br /><br>with patients who did not suffer a recurrent venous thrombotic event<br /><br>(controls).</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Determine associations between pathologic changes in the microbiome with<br /><br>factor VIII:C, D-dimer, clot lysis time and the endogenous thrombin potential<br /><br>- Determine associations between pathologic changes in the microbiome and<br /><br>complement activation<br /><br>- Determine associations between pathologic changes in the microbiome with AGEs<br /><br>- Determine associations between severity of periodontitis (expressed<br /><br>through PISA) and risk of recurrent venous thrombotic events.</p><br>