Effect of PEEP on Lung Regional Ventilation and Perfusion

Completed

• Conditions: Mechanical Ventilation Complication; Respiratory Failure; Hypoxia

• Registration Number: NCT04081155
• Lead Sponsor: Yun Long

Brief Summary

Investigate effects of PEEP on pulmonary regional ventilation and perfusion assessed by EIT

Detailed Description

1. When the research team was available, adult patients within 7days who were sequentially admitted to the Department of Critical Care Medicine and required central venous catheters and mechanically ventilation were eligible for the study.

2. Written informed consent was obtained from all patients or next of kin before data were included in the study.

3. Information collected at enrollment included demographic characteristics, such as age, sex.

4. The blood pressure（BP）,heart rate（HR）, pulse O2（SpO2）,tidal volume and lung regional ventilation and perfusion were collected at PEEP 0 centimeter H2O column and PEEP 12-15 centimeter H2O column.

5. Indicator-based EIT method: rapidly inject 10ml 10% Sodium chloride（NaCL） through central venous catheter during a 8s respiratory hold, and the curve of impedence change was collected by EIT machine

Study Timeline

• Status Verified: 2019-01
• Study Start: 2019-01-01
• Study First Submitted: 2019-09-03
• Study First Submitted QC: 2019-09-04
• Study First Posted: 2019-09-09
• Primary Completion: 2020-05-28
• Study Completion: 2020-06-01
• Last Update Submitted: 2020-07-12
• Last Update Posted: 2020-07-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

1. have been placed central venous catheter based on patient's condition
2. Under mechanically ventilation
3. Under sedation and control ventilation mode
4. Year>18

Exclusion Criteria

1. Pneumothorax
2. pregnancy
3. Severe chest wall wound
4. Severe hypernatremia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
lung regional perfusion distribution	Hour 1	lung regional perfusion distribution measured by EIT
lung regional ventilation distribution	Hour 1	lung regional ventilation distribution measured by EIT

Trial Locations

Locations (1)

Peking Union Medical College Hospital, Chinese Academy of Medical Science; 🇨🇳 Beijing, Beijing, China