Periostin Levels in Children With Adenoid Hypertrophy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Adenoid tissue Periostin level
研究概览
简要总结
Periostin is a matricellular protein that has been shown to be a marker of Type 2 inflammation associated with airway eosinophilia. Matricellular proteins are highly expressed at sites of injury or inflammation. Periostin involves tissue fibrosis and remodeling in the nasal mucosa in some of the otolaryngologic diseases. The up-regulation of periostin expression has been shown in allergic rhinitis, chronic rhinosinusitis with nasal polyps , and aspirin intolerant asthma. In the light of these findings the investigators aimed to evaluate the relation between adenoid hypertrophy and periostin levels.
详细描述
A total of 40 patients-age ranged between 2 and 12 years- were planned to enroll in the study prospectively. Patients that were scheduled to undergo adenoidectomy were included in the study group (adenoid group). The control group comprised of 20 healthy children who had previously been treated for anemia in the out-patient clinic of the Pediatrics Department and were clinically healthy with normal complete blood cell counts at their follow-up visits.
Serum samples were obtained from the two groups. The samples were centrifuged at 1500 g for 5 minute and stored in -80 oC for later analysis of periostin levels. Adenoid tissue and normal mucosal tissue samples were obtained from the adenoidectomy patients and stored in -80 oC for later homogenization and measurement of periostin levels.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The patients that were scheduled for adenoidectomy
- •Healthy subjects that had not any kind of allergy, adenoid hypertrophy symptoms
- •Exclusion Criteria(for adenoid group):
- •The subjects that had any kind of corticosteroid treatment 1 month prior to surgery, and antihistaminic treatment 2 weeks prior to surgery
- •Exclusion Criteria(for control group):
- •To have allergic rhinitis symptoms
- •To have high total IgE levels
- •To have positive skin prick test
- •To have acute respiratory tract infection
- •To have asthma To have any kind of endocrin disease
排除标准
- 未提供
结局指标
主要结局
Adenoid tissue Periostin level
时间窗: 1 month
Periostin levels of the adenoid tissue and normal mucosal healthy tissue will be compared.
Serum Periostin level
时间窗: 1 month
Serum periostin levels of the adenoid group and control group will be compared.
次要结局
未报告次要终点