Influences of Phenylephrine, Dopamine and Ephedrine on Stroke Volume Variation and Pulse Pressure Variation

Not Applicable

Completed

• Conditions: Drug Dose; Calculated SAP; Circulation
• Interventions: Other: Influences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variation

• Registration Number: NCT02201121
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

Although induced hypertension decreased SVV and PPV,the influences of stroke volume variation and pulse pressure variation caused by phenylephrine,dopamine and ephedrine were unknown.

Detailed Description

Pulse pressure variation (PPV) and stroke volume variation (SVV) during mechanical ventilation have been shown to be effective parameters to predict preload responsiveness. Although induced hypertension decreases PPV and SVV, the influences of phenylephrine, dopamine and ephedrine on PPV and SVV are unknown.

Study Timeline

• Status Verified: 2013-10
• Study Start: 2014-03
• Primary Completion: 2014-06
• Study Completion: 2014-06
• Study First Submitted: 2014-07-22
• Study First Submitted QC: 2014-07-24
• Last Update Submitted: 2014-07-24
• Study First Posted: 2014-07-25
• Last Update Posted: 2014-07-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 94

Inclusion Criteria

• Their American Society of Anesthesiologists (ASA) physical status was 1 or 2
• Body mass index (BMI) ranged from 18 to 26
• None of the patients had known diabetes mellitus, hypertension, cardiovascular, pulmonary, endocrinological, neurological diseases, or diseases that influenced intravascular fluid volume or balance
• All patients had a preoperative fast for at least 8 h and routine atropine intramuscular injection

Exclusion Criteria

• Persistent arrhythmias
• Intraoperative application of vasoactive drugs except phenylephrine, dopamine and ephedrine

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
phenylephrine group, dopamine group, ephedrine group	Influences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variation	phenylephrine group: use the phenylephrine to increase the SAP from low to high level. dopamine group: use the dopamine to increase the SAP from low to high level. ephedrine group:use the ephedrine to increase the SAP from low to high level.

Primary Outcome Measures

Name	Time	Method
invasive arterial blood pressure as a Measure of Safety	DAY 1	if instability of circulation, stop the clinical trial