Dexmedetomidine on Post-operative Blood Pressure in Bain Arteriovenous Malformation Embolization
- Registration Number
- NCT03076099
- Lead Sponsor
- Nan Jiang
- Brief Summary
Aim of this trial is to study the effect of Dexmedetomidine on post-operative blood pressure in patients undergoing brain arteriovenous malformation embolization. The patients were randomized allocated to either Dexmedetomidine group or Control group. Patients in Dexmedetomidine group will receive intravenous Dexmedetomidine while the control group will receive normal saline. Post-operative anti-hypertensive drug, Visual analogue score,post-operative analgesics consumption, Quality of Recovery score, Ramsay score, and adverse events were recorded.
- Detailed Description
Aim of this trial is to study the effect of Dexmedetomidine on post-operative blood pressure in patients undergoing brain arteriovenous malformation embolization. The patients were randomized allocated to either Dexmedetomidine group or Control group according to a random number. Patients in Dexmedetomidine group will receive intravenous Dexmedetomidine while the control group will receive normal saline. Post-operative anti-hypertensive drug, Visual analogue score,post-operative analgesics consumption, Quality of Recovery score-15 items, Ramsay score, and adverse events were recorded.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
- patients undergoing brain arteriovenous malformation embolization in the fist affiliated hospital, Sun Yat-sen University, aged 18-65 years, available to chat with,and the tracheal tube was extubated after surgery immediately.
- abuse anesthetic analgesics and sedative drugs, or allergic to Dexmedetomidine or other anesthetics, hypotension or bradycardia before surgery, severe pulmonary disease with saturation of pulse oximetry less than 90% before surgery, or patients refused to attend in this study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control group normal saline Normal Saline was administered intravenously when tracheal extubation,equal volume of normal saline was mixed with 100 ml normal saline and maintained 4 hours constantly. Dexmedetomidine Dexmedetomidine Dexmedetomidine was administered intravenously when tracheal extubation, 1.2μg/kg Dexmedetomidine was mixed with 100 ml normal saline and maintained 4 hours constantly.
- Primary Outcome Measures
Name Time Method urapidil consumption the end of the 6th hour after tracheal extubation urapidil consumption was recorded by nurses every hour
- Secondary Outcome Measures
Name Time Method Quality of Recovery Score the end of the 6th hour after tracheal extubation Quality of Recovery Score was measured by a 15-item quality of recovery scale
urapidil consumption on POD1 the total consumption of urapidil on post-operative day 1. urapidil consumption was recorded by nurses every hour
Quality of Recovery Score at 48th hour the end of the 48th hour after tracheal extubation Quality of Recovery Score was measured by a 15-item quality of recovery scale
Bradycardia the end of the 6th hour after tracheal extubation a heart rate of lower than 50 beats per minute was identified as bradycardia, frequency of bradycardia was recorded by nurse
PONV the end of the 6th hour after tracheal extubation post-operative nausea and vomiting (PONV) was recorded by nurse
Visual Analogue score at 48th hour the end of the 48th hour after tracheal extubation visual analogue score was measured by visual analogue scale
Analgesics consumption on POD1 the total consumption of urapidil on post-operative day 1. Analgesics consumption was recorded by nurse every hour
Bradycardia at 48th hour the end of the 48th hour after tracheal extubation a heart rate of lower than 50 beats per minute was identified as bradycardia, frequency of bradycardia was recorded by nurse
PONV at 24th hour the end of the 24th hour after tracheal extubation post-operative nausea and vomiting (PONV) was recorded by nurse
urapidil consumption on POD2 the total consumption of urapidil on post-operative day 2. urapidil consumption was recorded by nurses every hour
Visual Analogue score the end of the 6th hour after tracheal extubation visual analogue score was measured by visual analogue scale
Visual Analogue score at 24th hour the end of the 24th hour after tracheal extubation visual analogue score was measured by visual analogue scale
Quality of Recovery Score at 24th hour the end of the 24th hour after tracheal extubation Quality of Recovery Score was measured by a 15-item quality of recovery scale
Bradycardia at 24th hour the end of the 24th hour after tracheal extubation a heart rate of lower than 50 beats per minute was identified as bradycardia, frequency of bradycardia was recorded by nurse
Analgesics consumption the end of the 6th hour after tracheal extubation Analgesics consumption was recorded by nurse every hour
Analgesics consumption on POD2 the total consumption of urapidil on post-operative day 2. Analgesics consumption was recorded by nurse every hour
PONV at 48th hour the end of the 48th hour after tracheal extubation post-operative nausea and vomiting (PONV) was recorded by nurse
Trial Locations
- Locations (1)
the First Affiliated Hospital of Sun Yetsen University
🇨🇳Guangzhou, Guangdong, China