Effects of Dexmedetomidine on Modulation of Perioperative Blood Glucose and Related Hormones

Not Applicable

Completed

• Conditions: Dexmedetomidine; Blood Glucose
• Interventions: Drug: dexmedetomidine

• Registration Number: NCT03788538
• Lead Sponsor: Zhuan Zhang

Brief Summary

The investigators aimed to explore effects of dexmedetomidine on modulation of perioperative blood glucose and relevant hormone during the general anesthesia with surgery time ≥ 4 hours, and the effects on postoperative complications. 75 participants (American Society of Anesthesiologists grades I or II, of both sexes,aged 40-80 yr,with BMI of 18.5-27 kg/m2) scheduled for elective surgery under general anesthesia with surgery time ≥ 4 hours were enrolled in this study. The participants were divided into four groups: group C (control saline group, no dexmedetomidine use), group D1 (dexmedetomidine loading dose 1 mcg/kg, maintenance dose 0.25 mcg/kg/h), group D2 (dexmedetomidine loading dose 1 mcg/kg, maintenance dose 0.5 mcg/kg/h).10 minutes before anesthesia induction, all participants were administrated with dexmedetomidine 1 μg/kg/min.At the beginning of induction, dexmedetomidine was changed to corresponding maintenance dose in each group. Blood samples were taken at the beginning of dexmedetomidine (T0), the beginning of skin incision (T1), 1 h after skin incision (T2), the end of the surgery (T3) and 1 h after patient transfer to PACU (T4) for the value of blood glucose,lactate and relevant hormones. Also, investigators also record the total amount of propofol and sufentanil at the end of surgery,and the complications within 24 h after the surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-11-01
• Study First Submitted: 2018-12-25
• Study First Submitted QC: 2018-12-26
• Study First Posted: 2018-12-27
• Primary Completion: 2020-06-01
• Study Completion: 2020-06-01
• Status Verified: 2021-01
• Last Update Submitted: 2021-01-29
• Last Update Posted: 2021-02-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• patients undergoing operations over 4 h under general anesthesia,ASA physical status I or II, irrespective of showing gender bias, aged between 50-75 years old, and having a body mass index (BMI) between 18.5-28 kg/m2.

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Exclusion Criteria

• the patients with bradycardia, hypoglycemia, heart disease, adrenal tumor,diabetes or showed ≥7.0 mmol/L, or HbA1c level ≥6.5%.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group 2 with dexmedetomidine 0.25μg/kg/h	dexmedetomidine	-
group 2 with dexmedetomidine 0.5μg/kg/h	dexmedetomidine	-

Primary Outcome Measures

Name	Time	Method
Effects of dexmedetomidine on perioperative blood glucose (mmol/L)	before dexmedetomidine infusion, 1 hour after incision, at the end of surgery, 1 hour after patient transfer to postanesthesia care unit..	The changes of blood glucose during the surgery period
Effects of dexmedetomidine on perioperative insulin (μIU/ml)	before dexmedetomidine infusion, 1 hour after incision, at the end of surgery, 1 hour after patient transfer to postanesthesia care unit.	The changes of insulin during the surgery period
Effects of dexmedetomidine on perioperative glucagon and catecholamine (pg/ml)	before dexmedetomidine infusion, 1 hour after incision, at the end of surgery, 1 hour after patient transfer to postanesthesia care unit.	The changes of glucagon and catecholamine during the surgery period
Effects of dexmedetomidine on perioperative cortisol (ng/ml)	before dexmedetomidine infusion, 1 hour after incision, at the end of surgery, 1 hour after patient transfer to postanesthesia care unit.	The changes of cortisol during the surgery period

Trial Locations

Locations (1)

the Affiliated Hospital of Yangzhou University, Yangzhou University; 🇨🇳 Yangzhou, Jiangsu, China