A study to know the effect of Simvastatin gel on bone formatio
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Patients suffering from Chronic Periodontitis
- Registration Number
- CTRI/2016/11/007428
- Lead Sponsor
- KLE Society Institute of Dental Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
•Systemically healthy patient diagnosed with generalised chronic periodontitis
•Clinical probing pocket depth >= 5 mm.
•Radiographic evidence of bilateral intrabony defects in mandibular molar region
Exclusion Criteria
- History of antibiotics in last 6 months
- History of periodontal therapy in last 6 months
- Suspected allergy to statin group
- Patients on systemic statin therapy
- Patients having Aggressive periodontitis
- Current smokers
- Immunocompromised patient
- Pregnant and lactating females
- Patients having any bleeding disorders
- Any other contraindication for periodontal surgery
- Patients indicated for multiple extractions/undergone multiple extractions
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Amount of bone fill and percentage of original defect fill in Group 1 was statistically highly significant than Group 2 at the end of 6 and 9 months.Timepoint: 3 months, 6 months and 9 months.
- Secondary Outcome Measures
Name Time Method Both group resulted in significant improvement of both clinical and radiological parameters. There was significant reduction of Gingival Index (GI) , Probing pocket Depth (PPD) and gain in Clinical attachment level (CAL) was observed at the end of 3.6 and 9 months.Timepoint: 3 months, 6 months and 9 months