Effect of atorvastatin gel on GCF cytokines of patients with chronic periodontitis

Phase 3

Recruiting

Conditions: chronic periodontitis.
Chronic periodontitis
K05.3

Registration Number: IRCT20150210021029N5

Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 20

Inclusion Criteria

Having mild to moderate chronic periodontitis (bone crest distance from CEJ>2, Clinical Attachment Loss=3)
Having at least 20 teeth
Not having a bridge, crown, or orthodontic braces in the gel application area
Having at least 2 pockets with 4-7mm of probing depth and CAL of equal to or greater than 3mm

Exclusion Criteria

Having systemic diseases
Nonconformity of the prescribed diet
Pregnancy and lactation
Showing coronavirus disease symptoms or similar symptoms
Receiving periodontal treatment and/or usage of antibiotics during 1 month before treatment
Presence of aggressive periodontitis and systemic conditions affecting the periodontal condition
Malnutrition and impaired immune status
Smoking
Using statins or allergy to them
Using drugs that affect oral tissues
Use of antibiotics
Use of cholesterol-lowering drugs such as statins

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean IL-17 level. Timepoint: At baseline (before the intervention) and at 3 months after gel application. Method of measurement: ELISA Il-17 Human Kit.;Mean TGF-ß level. Timepoint: At baseline (before the intervention) and at 3 months after gel application. Method of measurement: ELISA TGF-ß Human Kit.

Secondary Outcome Measures